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Pubertal induction and transition to adult sex hormone replacement in patients with congenital pituitary or gonadal reproductive hormone deficiency: an Endo-ERN clinical practice guideline

An Endo-European Reference Network guideline initiative was launched including 16 clinicians experienced in endocrinology, pediatric and adult and 2 patient representatives. The guideline was endorsed by the European Society for Pediatric Endocrinology, the European Society for Endocrinology and the...

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Autores principales: Nordenström, A, Ahmed, S F, van den Akker, E, Blair, J, Bonomi, M, Brachet, C, Broersen, L H A, Claahsen-van der Grinten, H L, Dessens, A B, Gawlik, A, Gravholt, C H, Juul, A, Krausz, C, Raivio, T, Smyth, A, Touraine, P, Vitali, D, Dekkers, O M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066594/
https://www.ncbi.nlm.nih.gov/pubmed/35353710
http://dx.doi.org/10.1530/EJE-22-0073
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author Nordenström, A
Ahmed, S F
van den Akker, E
Blair, J
Bonomi, M
Brachet, C
Broersen, L H A
Claahsen-van der Grinten, H L
Dessens, A B
Gawlik, A
Gravholt, C H
Juul, A
Krausz, C
Raivio, T
Smyth, A
Touraine, P
Vitali, D
Dekkers, O M
author_facet Nordenström, A
Ahmed, S F
van den Akker, E
Blair, J
Bonomi, M
Brachet, C
Broersen, L H A
Claahsen-van der Grinten, H L
Dessens, A B
Gawlik, A
Gravholt, C H
Juul, A
Krausz, C
Raivio, T
Smyth, A
Touraine, P
Vitali, D
Dekkers, O M
author_sort Nordenström, A
collection PubMed
description An Endo-European Reference Network guideline initiative was launched including 16 clinicians experienced in endocrinology, pediatric and adult and 2 patient representatives. The guideline was endorsed by the European Society for Pediatric Endocrinology, the European Society for Endocrinology and the European Academy of Andrology. The aim was to create practice guidelines for clinical assessment and puberty induction in individuals with congenital pituitary or gonadal hormone deficiency. A systematic literature search was conducted, and the evidence was graded according to the Grading of Recommendations, Assessment, Development and Evaluation system. If the evidence was insufficient or lacking, then the conclusions were based on expert opinion. The guideline includes recommendations for puberty induction with oestrogen or testosterone. Publications on the induction of puberty with follicle-stimulation hormone and human chorionic gonadotrophin in hypogonadotropic hypogonadism are reviewed. Specific issues in individuals with Klinefelter syndrome or androgen insensitivity syndrome are considered. The expert panel recommends that pubertal induction or sex hormone replacement to sustain puberty should be cared for by a multidisciplinary team. Children with a known condition should be followed from the age of 8 years for girls and 9 years for boys. Puberty induction should be individualised but considered at 11 years in girls and 12 years in boys. Psychological aspects of puberty and fertility issues are especially important to address in individuals with sex development disorders or congenital pituitary deficiencies. The transition of these young adults highlights the importance of a multidisciplinary approach, to discuss both medical issues and social and psychological issues that arise in the context of these chronic conditions.
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spelling pubmed-90665942022-05-04 Pubertal induction and transition to adult sex hormone replacement in patients with congenital pituitary or gonadal reproductive hormone deficiency: an Endo-ERN clinical practice guideline Nordenström, A Ahmed, S F van den Akker, E Blair, J Bonomi, M Brachet, C Broersen, L H A Claahsen-van der Grinten, H L Dessens, A B Gawlik, A Gravholt, C H Juul, A Krausz, C Raivio, T Smyth, A Touraine, P Vitali, D Dekkers, O M Eur J Endocrinol Clinical Practice Guideline An Endo-European Reference Network guideline initiative was launched including 16 clinicians experienced in endocrinology, pediatric and adult and 2 patient representatives. The guideline was endorsed by the European Society for Pediatric Endocrinology, the European Society for Endocrinology and the European Academy of Andrology. The aim was to create practice guidelines for clinical assessment and puberty induction in individuals with congenital pituitary or gonadal hormone deficiency. A systematic literature search was conducted, and the evidence was graded according to the Grading of Recommendations, Assessment, Development and Evaluation system. If the evidence was insufficient or lacking, then the conclusions were based on expert opinion. The guideline includes recommendations for puberty induction with oestrogen or testosterone. Publications on the induction of puberty with follicle-stimulation hormone and human chorionic gonadotrophin in hypogonadotropic hypogonadism are reviewed. Specific issues in individuals with Klinefelter syndrome or androgen insensitivity syndrome are considered. The expert panel recommends that pubertal induction or sex hormone replacement to sustain puberty should be cared for by a multidisciplinary team. Children with a known condition should be followed from the age of 8 years for girls and 9 years for boys. Puberty induction should be individualised but considered at 11 years in girls and 12 years in boys. Psychological aspects of puberty and fertility issues are especially important to address in individuals with sex development disorders or congenital pituitary deficiencies. The transition of these young adults highlights the importance of a multidisciplinary approach, to discuss both medical issues and social and psychological issues that arise in the context of these chronic conditions. Bioscientifica Ltd 2022-03-29 /pmc/articles/PMC9066594/ /pubmed/35353710 http://dx.doi.org/10.1530/EJE-22-0073 Text en © The authors https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License. (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Clinical Practice Guideline
Nordenström, A
Ahmed, S F
van den Akker, E
Blair, J
Bonomi, M
Brachet, C
Broersen, L H A
Claahsen-van der Grinten, H L
Dessens, A B
Gawlik, A
Gravholt, C H
Juul, A
Krausz, C
Raivio, T
Smyth, A
Touraine, P
Vitali, D
Dekkers, O M
Pubertal induction and transition to adult sex hormone replacement in patients with congenital pituitary or gonadal reproductive hormone deficiency: an Endo-ERN clinical practice guideline
title Pubertal induction and transition to adult sex hormone replacement in patients with congenital pituitary or gonadal reproductive hormone deficiency: an Endo-ERN clinical practice guideline
title_full Pubertal induction and transition to adult sex hormone replacement in patients with congenital pituitary or gonadal reproductive hormone deficiency: an Endo-ERN clinical practice guideline
title_fullStr Pubertal induction and transition to adult sex hormone replacement in patients with congenital pituitary or gonadal reproductive hormone deficiency: an Endo-ERN clinical practice guideline
title_full_unstemmed Pubertal induction and transition to adult sex hormone replacement in patients with congenital pituitary or gonadal reproductive hormone deficiency: an Endo-ERN clinical practice guideline
title_short Pubertal induction and transition to adult sex hormone replacement in patients with congenital pituitary or gonadal reproductive hormone deficiency: an Endo-ERN clinical practice guideline
title_sort pubertal induction and transition to adult sex hormone replacement in patients with congenital pituitary or gonadal reproductive hormone deficiency: an endo-ern clinical practice guideline
topic Clinical Practice Guideline
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066594/
https://www.ncbi.nlm.nih.gov/pubmed/35353710
http://dx.doi.org/10.1530/EJE-22-0073
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