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Serum irisin levels increase in girls with central precocious puberty not dependent on BMI: a pilot study
OBJECTIVE: The objective of this study is to investigate the role of serum irisin level in diagnosis of central precocious puberty (CPP) in girls and its major determinants. METHODS: This study was conducted in 67 girls with CPP, 19 girls with premature thelarche (PT) and 59 normal controls. The maj...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bioscientifica Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066598/ https://www.ncbi.nlm.nih.gov/pubmed/35258485 http://dx.doi.org/10.1530/EC-22-0028 |
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author | Chen, Yanfei Li, Mei Liao, Binrong Zhong, Jingzi Lan, Dan |
author_facet | Chen, Yanfei Li, Mei Liao, Binrong Zhong, Jingzi Lan, Dan |
author_sort | Chen, Yanfei |
collection | PubMed |
description | OBJECTIVE: The objective of this study is to investigate the role of serum irisin level in diagnosis of central precocious puberty (CPP) in girls and its major determinants. METHODS: This study was conducted in 67 girls with CPP, 19 girls with premature thelarche (PT) and 59 normal controls. The major determinants of irisin were assessed by multivariate linear regression (MLR) analysis. Propensity score matching (PSM) analysis was performed to minimize the bias that can result from BMI. A receiver operating characteristic curve was used to obtain the optimal threshold value of irisin. RESULTS: The girls with CPP and PT had higher irisin levels than controls (P < 0.05). The optimal cutoff value of irisin levels for predicting CPP was 91.88 ng/mL, with a sensitivity of 70.1% and a specificity of 72.9%. MLR analysis showed that BMI was a predictor of irisin (P < 0.05). Serum irisin levels remained higher in the CPP girls than the controls with adjustment for BMI (P < 0.05). CONCLUSIONS: Increased serum irisin levels with CPP suggest that irisin is involved in puberty. However, due to low sensitivity and specificity, irisin level can only be used as an auxiliary indicator rather than a single diagnostic indicator of CPP. |
format | Online Article Text |
id | pubmed-9066598 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Bioscientifica Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-90665982022-05-04 Serum irisin levels increase in girls with central precocious puberty not dependent on BMI: a pilot study Chen, Yanfei Li, Mei Liao, Binrong Zhong, Jingzi Lan, Dan Endocr Connect Research OBJECTIVE: The objective of this study is to investigate the role of serum irisin level in diagnosis of central precocious puberty (CPP) in girls and its major determinants. METHODS: This study was conducted in 67 girls with CPP, 19 girls with premature thelarche (PT) and 59 normal controls. The major determinants of irisin were assessed by multivariate linear regression (MLR) analysis. Propensity score matching (PSM) analysis was performed to minimize the bias that can result from BMI. A receiver operating characteristic curve was used to obtain the optimal threshold value of irisin. RESULTS: The girls with CPP and PT had higher irisin levels than controls (P < 0.05). The optimal cutoff value of irisin levels for predicting CPP was 91.88 ng/mL, with a sensitivity of 70.1% and a specificity of 72.9%. MLR analysis showed that BMI was a predictor of irisin (P < 0.05). Serum irisin levels remained higher in the CPP girls than the controls with adjustment for BMI (P < 0.05). CONCLUSIONS: Increased serum irisin levels with CPP suggest that irisin is involved in puberty. However, due to low sensitivity and specificity, irisin level can only be used as an auxiliary indicator rather than a single diagnostic indicator of CPP. Bioscientifica Ltd 2022-03-08 /pmc/articles/PMC9066598/ /pubmed/35258485 http://dx.doi.org/10.1530/EC-22-0028 Text en © The authors https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. (https://creativecommons.org/licenses/by-nc/4.0/) |
spellingShingle | Research Chen, Yanfei Li, Mei Liao, Binrong Zhong, Jingzi Lan, Dan Serum irisin levels increase in girls with central precocious puberty not dependent on BMI: a pilot study |
title | Serum irisin levels increase in girls with central precocious puberty not dependent on BMI: a pilot study |
title_full | Serum irisin levels increase in girls with central precocious puberty not dependent on BMI: a pilot study |
title_fullStr | Serum irisin levels increase in girls with central precocious puberty not dependent on BMI: a pilot study |
title_full_unstemmed | Serum irisin levels increase in girls with central precocious puberty not dependent on BMI: a pilot study |
title_short | Serum irisin levels increase in girls with central precocious puberty not dependent on BMI: a pilot study |
title_sort | serum irisin levels increase in girls with central precocious puberty not dependent on bmi: a pilot study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066598/ https://www.ncbi.nlm.nih.gov/pubmed/35258485 http://dx.doi.org/10.1530/EC-22-0028 |
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