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Association of maternal thyroid dysfunction and autoimmunity with adverse birth outcomes

This study aimed to explore the relationship between thyroid function and autoimmunity and adverse birth outcomes. Serum levels of thyroid function were detected by electrochemiluminescence assay. Urine iodine concentration was detected using the acid digestion method. We used multiple linear regres...

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Autores principales: He, Xin, Yan, Qin, Liu, Chazhen, Wang, Zhengyuan, Liao, Ping, Liu, Tong, Shi, Zehuan, Song, Qi, Cui, Xueying, Wang, Wenjing, Zang, Jiajie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066600/
https://www.ncbi.nlm.nih.gov/pubmed/35294399
http://dx.doi.org/10.1530/EC-21-0599
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author He, Xin
Yan, Qin
Liu, Chazhen
Wang, Zhengyuan
Liao, Ping
Liu, Tong
Shi, Zehuan
Song, Qi
Cui, Xueying
Wang, Wenjing
Zang, Jiajie
author_facet He, Xin
Yan, Qin
Liu, Chazhen
Wang, Zhengyuan
Liao, Ping
Liu, Tong
Shi, Zehuan
Song, Qi
Cui, Xueying
Wang, Wenjing
Zang, Jiajie
author_sort He, Xin
collection PubMed
description This study aimed to explore the relationship between thyroid function and autoimmunity and adverse birth outcomes. Serum levels of thyroid function were detected by electrochemiluminescence assay. Urine iodine concentration was detected using the acid digestion method. We used multiple linear regression to assess the correlation between thyroid function indicators and birth weight according to trimester stratification and binary logistic regression to evaluate the correlation between thyroid dysfunction and adverse birth outcomes. Reference ranges for trimester-specific thyroid hormones were established in our 2564 pregnant women cohort with mild iodine deficiency. The higher the maternal thyroid-stimulating hormone in the first trimester (B = 0.09, P  = 0.048) and total triiodothyronine (TT3) in the third trimester (B = 0.16, P  < 0.001) of TPOAbnegative women, the higher the birth weight Z-score, whereas in the second trimester, free-thyroxine of mothers with TPOAb negative was lower (B = −0.10, P  = 0.026) and the birth weight Z-score was higher. Pregnant women with overt and subclinical hyperthyroidism had a higher risk of preterm births than euthyroid women (11.9% vs 4.5%; odds ratio (OR): 2.84; P  = 0.009). Women with higher TT3 had a higher risk of preterm (17.0% vs 4.5%; OR: 4.19; P  < 0.001) and LGA (34.0% vs 11.1%; OR: 3.70; P  < 0.001) births than euthyroid women. In conclusion, thyroid function during pregnancy could affect birth weight and birth outcome.
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spelling pubmed-90666002022-05-04 Association of maternal thyroid dysfunction and autoimmunity with adverse birth outcomes He, Xin Yan, Qin Liu, Chazhen Wang, Zhengyuan Liao, Ping Liu, Tong Shi, Zehuan Song, Qi Cui, Xueying Wang, Wenjing Zang, Jiajie Endocr Connect Research This study aimed to explore the relationship between thyroid function and autoimmunity and adverse birth outcomes. Serum levels of thyroid function were detected by electrochemiluminescence assay. Urine iodine concentration was detected using the acid digestion method. We used multiple linear regression to assess the correlation between thyroid function indicators and birth weight according to trimester stratification and binary logistic regression to evaluate the correlation between thyroid dysfunction and adverse birth outcomes. Reference ranges for trimester-specific thyroid hormones were established in our 2564 pregnant women cohort with mild iodine deficiency. The higher the maternal thyroid-stimulating hormone in the first trimester (B = 0.09, P  = 0.048) and total triiodothyronine (TT3) in the third trimester (B = 0.16, P  < 0.001) of TPOAbnegative women, the higher the birth weight Z-score, whereas in the second trimester, free-thyroxine of mothers with TPOAb negative was lower (B = −0.10, P  = 0.026) and the birth weight Z-score was higher. Pregnant women with overt and subclinical hyperthyroidism had a higher risk of preterm births than euthyroid women (11.9% vs 4.5%; odds ratio (OR): 2.84; P  = 0.009). Women with higher TT3 had a higher risk of preterm (17.0% vs 4.5%; OR: 4.19; P  < 0.001) and LGA (34.0% vs 11.1%; OR: 3.70; P  < 0.001) births than euthyroid women. In conclusion, thyroid function during pregnancy could affect birth weight and birth outcome. Bioscientifica Ltd 2022-03-16 /pmc/articles/PMC9066600/ /pubmed/35294399 http://dx.doi.org/10.1530/EC-21-0599 Text en © The authors https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Research
He, Xin
Yan, Qin
Liu, Chazhen
Wang, Zhengyuan
Liao, Ping
Liu, Tong
Shi, Zehuan
Song, Qi
Cui, Xueying
Wang, Wenjing
Zang, Jiajie
Association of maternal thyroid dysfunction and autoimmunity with adverse birth outcomes
title Association of maternal thyroid dysfunction and autoimmunity with adverse birth outcomes
title_full Association of maternal thyroid dysfunction and autoimmunity with adverse birth outcomes
title_fullStr Association of maternal thyroid dysfunction and autoimmunity with adverse birth outcomes
title_full_unstemmed Association of maternal thyroid dysfunction and autoimmunity with adverse birth outcomes
title_short Association of maternal thyroid dysfunction and autoimmunity with adverse birth outcomes
title_sort association of maternal thyroid dysfunction and autoimmunity with adverse birth outcomes
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066600/
https://www.ncbi.nlm.nih.gov/pubmed/35294399
http://dx.doi.org/10.1530/EC-21-0599
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