NDR1 increases NOTCH1 signaling activity by impairing Fbw7 mediated NICD degradation to enhance breast cancer stem cell properties

BACKGROUND: The existence of breast cancer stem cells (BCSCs) causes tumor relapses, metastasis and resistance to conventional therapy in breast cancer. NDR1 kinase, a component of the Hippo pathway, plays important roles in multiple biological processes. However, its role in cancer stem cells has n...

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Detalles Bibliográficos
Autores principales: Wang, Ling-Ling, Wan, Xiao-Yun, Liu, Chun-Qi, Zheng, Fei-Meng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066784/
https://www.ncbi.nlm.nih.gov/pubmed/35508987
http://dx.doi.org/10.1186/s10020-022-00480-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066784/
https://www.ncbi.nlm.nih.gov/pubmed/35508987
http://dx.doi.org/10.1186/s10020-022-00480-x

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