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Specific antibody titer decay in neonates prenatally exposed to Toxoplasma gondii and their mothers

BACKGROUND: For infants exposed in utero to Toxoplasma gondii, current guidelines recommend monitoring the specific antibody titer until 12 months of age. In this study, we investigated the antibody titer decay in the mother-infant dyad. METHODS: This is a single center, population-based cohort stud...

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Autores principales: Salomè, Serena, Grieco, Claudia, Barra, Pasquale Fabio, Capone, Eleonora, Grasso, Fiorentino, Carraturo, Francesca, Dolce, Pasquale, Salvatore, Paola, Capasso, Letizia, Raimondi, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066792/
https://www.ncbi.nlm.nih.gov/pubmed/35505374
http://dx.doi.org/10.1186/s13052-022-01261-2
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author Salomè, Serena
Grieco, Claudia
Barra, Pasquale Fabio
Capone, Eleonora
Grasso, Fiorentino
Carraturo, Francesca
Dolce, Pasquale
Salvatore, Paola
Capasso, Letizia
Raimondi, Francesco
author_facet Salomè, Serena
Grieco, Claudia
Barra, Pasquale Fabio
Capone, Eleonora
Grasso, Fiorentino
Carraturo, Francesca
Dolce, Pasquale
Salvatore, Paola
Capasso, Letizia
Raimondi, Francesco
author_sort Salomè, Serena
collection PubMed
description BACKGROUND: For infants exposed in utero to Toxoplasma gondii, current guidelines recommend monitoring the specific antibody titer until 12 months of age. In this study, we investigated the antibody titer decay in the mother-infant dyad. METHODS: This is a single center, population-based cohort study of neonates referred for prenatal exposure to Toxoplasma gondii from January 2014 to December 2020. All infants underwent clinical, laboratory, and instrumental investigation for at least 12 months. RESULTS: A total of 670 eligible neonates were referred to the Perinatal Infection Unit of the University Federico II of Naples. 636 (95%) completed the serological follow up until 12 months. Specific IgG antibodies negativization occurred in 628 (98.7%) within 5 months. At 9 and 12 months, all patients had negative IgG. An initial neonatal IgG antibody titer ≥ 200 IU/ml was associated with a longer time to negativization (184 [177.5;256] days when above threshold vs. 139.5 [101;179] days when below it; p < 0.001). Maternal IgG antibody titer ≥ 200 IU/ml at childbirth was also associated to delayed time to negativization in the infant (179 [163;184] days above the threshold vs 125 [96.8;178] days below it; p < 0.001). Specific antibody negativization was irreversible in all patients. CONCLUSIONS: Lower anti-Toxoplasma antibody titers detected at birth in the mother-infant-dyad lead to an earlier and irreversible negativization. This information allows for customisation of the infant follow up program and avoids invasive and expensive tests.
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spelling pubmed-90667922022-05-04 Specific antibody titer decay in neonates prenatally exposed to Toxoplasma gondii and their mothers Salomè, Serena Grieco, Claudia Barra, Pasquale Fabio Capone, Eleonora Grasso, Fiorentino Carraturo, Francesca Dolce, Pasquale Salvatore, Paola Capasso, Letizia Raimondi, Francesco Ital J Pediatr Research BACKGROUND: For infants exposed in utero to Toxoplasma gondii, current guidelines recommend monitoring the specific antibody titer until 12 months of age. In this study, we investigated the antibody titer decay in the mother-infant dyad. METHODS: This is a single center, population-based cohort study of neonates referred for prenatal exposure to Toxoplasma gondii from January 2014 to December 2020. All infants underwent clinical, laboratory, and instrumental investigation for at least 12 months. RESULTS: A total of 670 eligible neonates were referred to the Perinatal Infection Unit of the University Federico II of Naples. 636 (95%) completed the serological follow up until 12 months. Specific IgG antibodies negativization occurred in 628 (98.7%) within 5 months. At 9 and 12 months, all patients had negative IgG. An initial neonatal IgG antibody titer ≥ 200 IU/ml was associated with a longer time to negativization (184 [177.5;256] days when above threshold vs. 139.5 [101;179] days when below it; p < 0.001). Maternal IgG antibody titer ≥ 200 IU/ml at childbirth was also associated to delayed time to negativization in the infant (179 [163;184] days above the threshold vs 125 [96.8;178] days below it; p < 0.001). Specific antibody negativization was irreversible in all patients. CONCLUSIONS: Lower anti-Toxoplasma antibody titers detected at birth in the mother-infant-dyad lead to an earlier and irreversible negativization. This information allows for customisation of the infant follow up program and avoids invasive and expensive tests. BioMed Central 2022-05-03 /pmc/articles/PMC9066792/ /pubmed/35505374 http://dx.doi.org/10.1186/s13052-022-01261-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Salomè, Serena
Grieco, Claudia
Barra, Pasquale Fabio
Capone, Eleonora
Grasso, Fiorentino
Carraturo, Francesca
Dolce, Pasquale
Salvatore, Paola
Capasso, Letizia
Raimondi, Francesco
Specific antibody titer decay in neonates prenatally exposed to Toxoplasma gondii and their mothers
title Specific antibody titer decay in neonates prenatally exposed to Toxoplasma gondii and their mothers
title_full Specific antibody titer decay in neonates prenatally exposed to Toxoplasma gondii and their mothers
title_fullStr Specific antibody titer decay in neonates prenatally exposed to Toxoplasma gondii and their mothers
title_full_unstemmed Specific antibody titer decay in neonates prenatally exposed to Toxoplasma gondii and their mothers
title_short Specific antibody titer decay in neonates prenatally exposed to Toxoplasma gondii and their mothers
title_sort specific antibody titer decay in neonates prenatally exposed to toxoplasma gondii and their mothers
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066792/
https://www.ncbi.nlm.nih.gov/pubmed/35505374
http://dx.doi.org/10.1186/s13052-022-01261-2
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