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Sporadic foveolar-type adenoma in gastric body/antrum junction with gastritis cystica profunda
BACKGROUND: Sporadic gastric foveolar-type adenomas are extremely rare and are usually small, flat or slightly raised lesions that occur in the oxyntic mucosa. CASE PRESENTATION: We reported here a case of a 70-year-old female with a sporadic gastric foveolar-type adenoma occurring in the mucosa at...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066893/ https://www.ncbi.nlm.nih.gov/pubmed/35508985 http://dx.doi.org/10.1186/s12876-022-02285-y |
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author | Guan, Jian Li, Zhuo Shen, Guihua Huang, Wenting |
author_facet | Guan, Jian Li, Zhuo Shen, Guihua Huang, Wenting |
author_sort | Guan, Jian |
collection | PubMed |
description | BACKGROUND: Sporadic gastric foveolar-type adenomas are extremely rare and are usually small, flat or slightly raised lesions that occur in the oxyntic mucosa. CASE PRESENTATION: We reported here a case of a 70-year-old female with a sporadic gastric foveolar-type adenoma occurring in the mucosa at the junction of the gastric body/antrum. The adenoma was a protruding lesion of 2 × 1.8 cm sized, causing symptoms of upper gastrointestinal bleeding, and the basal and surrounding mucosa showed pseudopyloric gland metaplasia without atrophy, intestinal metaplasia, H. pylori infection, or active inflammation. It had somatic mutations in both APC and KRAS genes. CONCLUSIONS: This is the first reported case of a large sporadic gastric foveolar-type adenoma that occurred in the mucosa of pseudopyloric gland metaplasia and with Gastritis Cystica Profunda, which modify our understanding of the morphological features and molecular underpinnings of this type of lesion. |
format | Online Article Text |
id | pubmed-9066893 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-90668932022-05-04 Sporadic foveolar-type adenoma in gastric body/antrum junction with gastritis cystica profunda Guan, Jian Li, Zhuo Shen, Guihua Huang, Wenting BMC Gastroenterol Case Report BACKGROUND: Sporadic gastric foveolar-type adenomas are extremely rare and are usually small, flat or slightly raised lesions that occur in the oxyntic mucosa. CASE PRESENTATION: We reported here a case of a 70-year-old female with a sporadic gastric foveolar-type adenoma occurring in the mucosa at the junction of the gastric body/antrum. The adenoma was a protruding lesion of 2 × 1.8 cm sized, causing symptoms of upper gastrointestinal bleeding, and the basal and surrounding mucosa showed pseudopyloric gland metaplasia without atrophy, intestinal metaplasia, H. pylori infection, or active inflammation. It had somatic mutations in both APC and KRAS genes. CONCLUSIONS: This is the first reported case of a large sporadic gastric foveolar-type adenoma that occurred in the mucosa of pseudopyloric gland metaplasia and with Gastritis Cystica Profunda, which modify our understanding of the morphological features and molecular underpinnings of this type of lesion. BioMed Central 2022-05-04 /pmc/articles/PMC9066893/ /pubmed/35508985 http://dx.doi.org/10.1186/s12876-022-02285-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Case Report Guan, Jian Li, Zhuo Shen, Guihua Huang, Wenting Sporadic foveolar-type adenoma in gastric body/antrum junction with gastritis cystica profunda |
title | Sporadic foveolar-type adenoma in gastric body/antrum junction with gastritis cystica profunda |
title_full | Sporadic foveolar-type adenoma in gastric body/antrum junction with gastritis cystica profunda |
title_fullStr | Sporadic foveolar-type adenoma in gastric body/antrum junction with gastritis cystica profunda |
title_full_unstemmed | Sporadic foveolar-type adenoma in gastric body/antrum junction with gastritis cystica profunda |
title_short | Sporadic foveolar-type adenoma in gastric body/antrum junction with gastritis cystica profunda |
title_sort | sporadic foveolar-type adenoma in gastric body/antrum junction with gastritis cystica profunda |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066893/ https://www.ncbi.nlm.nih.gov/pubmed/35508985 http://dx.doi.org/10.1186/s12876-022-02285-y |
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