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The Nuclear Proteins TP73 and CUL4A Confer Resistance to Cytarabine by Induction of Translesion DNA Synthesis via Mono-ubiquitination of PCNA

Resistance to cytarabine is a key problem in the treatment of acute myeloid leukemia (AML). To understand the molecular biology of resistance to cytarabine, a viability-based chemosensitizer screen was utilized. We screened synthetic lethal targets using 437 different small interfering RNAs (siRNAs)...

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Detalles Bibliográficos
Autores principales:	Rehberger, Miriam, Schäfer, Jonas A., Krampitz, Anna-Maria, Bretz, Anne Catherine, Jost, Lukas, Haferlach, Torsten, Stiewe, Thorsten, Neubauer, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067361/ https://www.ncbi.nlm.nih.gov/pubmed/35519003 http://dx.doi.org/10.1097/HS9.0000000000000708

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