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Examining empathy deficits across familial forms of frontotemporal dementia within the GENFI cohort
BACKGROUND: Reduced empathy is a common symptom in frontotemporal dementia (FTD). Although empathy deficits have been extensively researched in sporadic cases, few studies have explored the differences in familial forms of FTD. METHODS: Empathy was examined using a modified version of the Interperso...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Masson
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067453/ https://www.ncbi.nlm.nih.gov/pubmed/35325762 http://dx.doi.org/10.1016/j.cortex.2022.01.012 |
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author | Foster, Phoebe H. Russell, Lucy L. Peakman, Georgia Convery, Rhian S. Bouzigues, Arabella Greaves, Caroline V. Bocchetta, Martina Cash, David M. van Swieten, John C. Jiskoot, Lize C. Moreno, Fermin Sanchez-Valle, Raquel Laforce, Robert Graff, Caroline Masellis, Mario Tartaglia, Carmela Rowe, James B. Borroni, Barbara Finger, Elizabeth Synofzik, Matthis Galimberti, Daniela Vandenberghe, Rik de Mendonça, Alexandre Butler, Chris R. Gerhard, Alex Ducharme, Simon Le Ber, Isabelle Tagliavini, Fabrizio Santana, Isabel Pasquier, Florence Levin, Johannes Danek, Adrian Otto, Markus Sorbi, Sandro Rohrer, Jonathan D. |
author_facet | Foster, Phoebe H. Russell, Lucy L. Peakman, Georgia Convery, Rhian S. Bouzigues, Arabella Greaves, Caroline V. Bocchetta, Martina Cash, David M. van Swieten, John C. Jiskoot, Lize C. Moreno, Fermin Sanchez-Valle, Raquel Laforce, Robert Graff, Caroline Masellis, Mario Tartaglia, Carmela Rowe, James B. Borroni, Barbara Finger, Elizabeth Synofzik, Matthis Galimberti, Daniela Vandenberghe, Rik de Mendonça, Alexandre Butler, Chris R. Gerhard, Alex Ducharme, Simon Le Ber, Isabelle Tagliavini, Fabrizio Santana, Isabel Pasquier, Florence Levin, Johannes Danek, Adrian Otto, Markus Sorbi, Sandro Rohrer, Jonathan D. |
author_sort | Foster, Phoebe H. |
collection | PubMed |
description | BACKGROUND: Reduced empathy is a common symptom in frontotemporal dementia (FTD). Although empathy deficits have been extensively researched in sporadic cases, few studies have explored the differences in familial forms of FTD. METHODS: Empathy was examined using a modified version of the Interpersonal Reactivity Index (mIRI) in 676 participants from the Genetic FTD Initiative: 216 mutation-negative controls, 192 C9orf72 expansion carriers, 193 GRN mutation carriers and 75 MAPT mutation carriers. Using global scores from the CDR® plus NACC FTLD, mutation carriers were divided into three groups, asymptomatic (0), very mildly symptomatic/prodromal (.5), or fully symptomatic (1 or more). The mIRI Total score, as well as the subscores of Empathic Concern (EC) and Perspective Taking (PT) were assessed. Linear regression models with bootstrapping were used to assess empathy ratings across genetic groups, as well as across phenotypes in the symptomatic carriers. Neural correlates of empathy deficits were examined using a voxel-based morphometry (VBM) analysis. RESULTS: All fully symptomatic groups scored lower on the mIRI Total, EC, and PT when compared to controls and their asymptomatic or prodromal counterparts (all p < .001). Prodromal C9orf72 expansion carriers also scored significantly lower than controls on the mIRI Total score (p = .046). In the phenotype analysis, all groups (behavioural variant FTD, primary progressive aphasia and FTD with amyotrophic lateral sclerosis) scored significantly lower than controls (all p < .007). VBM revealed an overlapping neural correlate of the mIRI Total score across genetic groups in the orbitofrontal lobe but with additional involvement in the temporal lobe, insula and basal ganglia in both the GRN and MAPT groups, and uniquely more posterior regions such as the parietal lobe and thalamus in the GRN group, and medial temporal structures in the MAPT group. CONCLUSIONS: Significant empathy deficits present in genetic FTD, particularly in symptomatic individuals and those with a bvFTD phenotype, while prodromal deficits are only seen using the mIRI in C9orf72 expansion carriers. |
format | Online Article Text |
id | pubmed-9067453 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Masson |
record_format | MEDLINE/PubMed |
spelling | pubmed-90674532022-06-07 Examining empathy deficits across familial forms of frontotemporal dementia within the GENFI cohort Foster, Phoebe H. Russell, Lucy L. Peakman, Georgia Convery, Rhian S. Bouzigues, Arabella Greaves, Caroline V. Bocchetta, Martina Cash, David M. van Swieten, John C. Jiskoot, Lize C. Moreno, Fermin Sanchez-Valle, Raquel Laforce, Robert Graff, Caroline Masellis, Mario Tartaglia, Carmela Rowe, James B. Borroni, Barbara Finger, Elizabeth Synofzik, Matthis Galimberti, Daniela Vandenberghe, Rik de Mendonça, Alexandre Butler, Chris R. Gerhard, Alex Ducharme, Simon Le Ber, Isabelle Tagliavini, Fabrizio Santana, Isabel Pasquier, Florence Levin, Johannes Danek, Adrian Otto, Markus Sorbi, Sandro Rohrer, Jonathan D. Cortex Behavioural Neurology BACKGROUND: Reduced empathy is a common symptom in frontotemporal dementia (FTD). Although empathy deficits have been extensively researched in sporadic cases, few studies have explored the differences in familial forms of FTD. METHODS: Empathy was examined using a modified version of the Interpersonal Reactivity Index (mIRI) in 676 participants from the Genetic FTD Initiative: 216 mutation-negative controls, 192 C9orf72 expansion carriers, 193 GRN mutation carriers and 75 MAPT mutation carriers. Using global scores from the CDR® plus NACC FTLD, mutation carriers were divided into three groups, asymptomatic (0), very mildly symptomatic/prodromal (.5), or fully symptomatic (1 or more). The mIRI Total score, as well as the subscores of Empathic Concern (EC) and Perspective Taking (PT) were assessed. Linear regression models with bootstrapping were used to assess empathy ratings across genetic groups, as well as across phenotypes in the symptomatic carriers. Neural correlates of empathy deficits were examined using a voxel-based morphometry (VBM) analysis. RESULTS: All fully symptomatic groups scored lower on the mIRI Total, EC, and PT when compared to controls and their asymptomatic or prodromal counterparts (all p < .001). Prodromal C9orf72 expansion carriers also scored significantly lower than controls on the mIRI Total score (p = .046). In the phenotype analysis, all groups (behavioural variant FTD, primary progressive aphasia and FTD with amyotrophic lateral sclerosis) scored significantly lower than controls (all p < .007). VBM revealed an overlapping neural correlate of the mIRI Total score across genetic groups in the orbitofrontal lobe but with additional involvement in the temporal lobe, insula and basal ganglia in both the GRN and MAPT groups, and uniquely more posterior regions such as the parietal lobe and thalamus in the GRN group, and medial temporal structures in the MAPT group. CONCLUSIONS: Significant empathy deficits present in genetic FTD, particularly in symptomatic individuals and those with a bvFTD phenotype, while prodromal deficits are only seen using the mIRI in C9orf72 expansion carriers. Masson 2022-05 /pmc/articles/PMC9067453/ /pubmed/35325762 http://dx.doi.org/10.1016/j.cortex.2022.01.012 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Behavioural Neurology Foster, Phoebe H. Russell, Lucy L. Peakman, Georgia Convery, Rhian S. Bouzigues, Arabella Greaves, Caroline V. Bocchetta, Martina Cash, David M. van Swieten, John C. Jiskoot, Lize C. Moreno, Fermin Sanchez-Valle, Raquel Laforce, Robert Graff, Caroline Masellis, Mario Tartaglia, Carmela Rowe, James B. Borroni, Barbara Finger, Elizabeth Synofzik, Matthis Galimberti, Daniela Vandenberghe, Rik de Mendonça, Alexandre Butler, Chris R. Gerhard, Alex Ducharme, Simon Le Ber, Isabelle Tagliavini, Fabrizio Santana, Isabel Pasquier, Florence Levin, Johannes Danek, Adrian Otto, Markus Sorbi, Sandro Rohrer, Jonathan D. Examining empathy deficits across familial forms of frontotemporal dementia within the GENFI cohort |
title | Examining empathy deficits across familial forms of frontotemporal dementia within the GENFI cohort |
title_full | Examining empathy deficits across familial forms of frontotemporal dementia within the GENFI cohort |
title_fullStr | Examining empathy deficits across familial forms of frontotemporal dementia within the GENFI cohort |
title_full_unstemmed | Examining empathy deficits across familial forms of frontotemporal dementia within the GENFI cohort |
title_short | Examining empathy deficits across familial forms of frontotemporal dementia within the GENFI cohort |
title_sort | examining empathy deficits across familial forms of frontotemporal dementia within the genfi cohort |
topic | Behavioural Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067453/ https://www.ncbi.nlm.nih.gov/pubmed/35325762 http://dx.doi.org/10.1016/j.cortex.2022.01.012 |
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