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Mechanisms of ribosome recycling in bacteria and mitochondria: a structural perspective
In all living cells, the ribosome translates the genetic information carried by messenger RNAs (mRNAs) into proteins. The process of ribosome recycling, a key step during protein synthesis that ensures ribosomal subunits remain available for new rounds of translation, has been largely overlooked. De...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067457/ https://www.ncbi.nlm.nih.gov/pubmed/35485608 http://dx.doi.org/10.1080/15476286.2022.2067712 |
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author | Seely, Savannah M. Gagnon, Matthieu G. |
author_facet | Seely, Savannah M. Gagnon, Matthieu G. |
author_sort | Seely, Savannah M. |
collection | PubMed |
description | In all living cells, the ribosome translates the genetic information carried by messenger RNAs (mRNAs) into proteins. The process of ribosome recycling, a key step during protein synthesis that ensures ribosomal subunits remain available for new rounds of translation, has been largely overlooked. Despite being essential to the survival of the cell, several mechanistic aspects of ribosome recycling remain unclear. In eubacteria and mitochondria, recycling of the ribosome into subunits requires the concerted action of the ribosome recycling factor (RRF) and elongation factor G (EF-G). Recently, the conserved protein HflX was identified in bacteria as an alternative factor that recycles the ribosome under stress growth conditions. The homologue of HflX, the GTP-binding protein 6 (GTPBP6), has a dual role in mitochondrial translation by facilitating ribosome recycling and biogenesis. In this review, mechanisms of ribosome recycling in eubacteria and mitochondria are described based on structural studies of ribosome complexes. |
format | Online Article Text |
id | pubmed-9067457 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-90674572022-05-05 Mechanisms of ribosome recycling in bacteria and mitochondria: a structural perspective Seely, Savannah M. Gagnon, Matthieu G. RNA Biol Review In all living cells, the ribosome translates the genetic information carried by messenger RNAs (mRNAs) into proteins. The process of ribosome recycling, a key step during protein synthesis that ensures ribosomal subunits remain available for new rounds of translation, has been largely overlooked. Despite being essential to the survival of the cell, several mechanistic aspects of ribosome recycling remain unclear. In eubacteria and mitochondria, recycling of the ribosome into subunits requires the concerted action of the ribosome recycling factor (RRF) and elongation factor G (EF-G). Recently, the conserved protein HflX was identified in bacteria as an alternative factor that recycles the ribosome under stress growth conditions. The homologue of HflX, the GTP-binding protein 6 (GTPBP6), has a dual role in mitochondrial translation by facilitating ribosome recycling and biogenesis. In this review, mechanisms of ribosome recycling in eubacteria and mitochondria are described based on structural studies of ribosome complexes. Taylor & Francis 2022-04-29 /pmc/articles/PMC9067457/ /pubmed/35485608 http://dx.doi.org/10.1080/15476286.2022.2067712 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Seely, Savannah M. Gagnon, Matthieu G. Mechanisms of ribosome recycling in bacteria and mitochondria: a structural perspective |
title | Mechanisms of ribosome recycling in bacteria and mitochondria: a structural perspective |
title_full | Mechanisms of ribosome recycling in bacteria and mitochondria: a structural perspective |
title_fullStr | Mechanisms of ribosome recycling in bacteria and mitochondria: a structural perspective |
title_full_unstemmed | Mechanisms of ribosome recycling in bacteria and mitochondria: a structural perspective |
title_short | Mechanisms of ribosome recycling in bacteria and mitochondria: a structural perspective |
title_sort | mechanisms of ribosome recycling in bacteria and mitochondria: a structural perspective |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067457/ https://www.ncbi.nlm.nih.gov/pubmed/35485608 http://dx.doi.org/10.1080/15476286.2022.2067712 |
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