Physiologically Based Modeling to Predict Monoclonal Antibody Pharmacokinetics in Humans from in vitro Physiochemical Properties

A model-based framework is presented to predict monoclonal antibody (mAb) pharmacokinetics (PK) in humans based on in vitro measures of antibody physiochemical properties. A physiologically based pharmacokinetic (PBPK) model is used to explore the predictive potential of 14 in vitro assays designed...

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Detalles Bibliográficos
Autores principales: Hu, Shihao, Datta-Mannan, Amita, D’Argenio, David Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067474/
https://www.ncbi.nlm.nih.gov/pubmed/35491902
http://dx.doi.org/10.1080/19420862.2022.2056944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067474/
https://www.ncbi.nlm.nih.gov/pubmed/35491902
http://dx.doi.org/10.1080/19420862.2022.2056944

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