Overcoming T cell dysfunction in acidic pH to enhance adoptive T cell transfer immunotherapy

The high metabolic activity and insufficient perfusion of tumors leads to the acidification of the tumor microenvironment (TME) that may inhibit the antitumor T cell activity. We found that pharmacological inhibition of the acid loader chloride/bicarbonate anion exchanger 2 (Ae2), with 4,4’-diisothi...

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Detalles Bibliográficos
Autores principales: Navarro, Flor, Casares, Noelia, Martín-Otal, Celia, Lasarte-Cía, Aritz, Gorraiz, Marta, Sarrión, Patricia, Llopiz, Diana, Reparaz, David, Varo, Nerea, Rodriguez-Madoz, Juan Roberto, Prosper, Felipe, Hervás-Stubbs, Sandra, Lozano, Teresa, Lasarte, Juan José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067511/
https://www.ncbi.nlm.nih.gov/pubmed/35529677
http://dx.doi.org/10.1080/2162402X.2022.2070337

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