Peri-Anal and Genital Localization of Giant Condyloma Acuminatum or Buschke–Lowenstein’s Tumor: A Report of Two Cases

Buschke–Löwenstein’s tumor (BLT) is a skin tumor induced by a human papillomavirus (HPV) infection. HPV genotypes 6 and 11, which are of low oncogenic potential, are present in over 90% of condylomas. Genotypes 16 and 18 combine with factors related to immunosuppression and chronic irritation to promote exophytic and endophytic growth and malignant transformation. BLT is most common in men between the ages of 40 and 60, occurring most commonly in the genital area. Perianal localization is less frequent and raises the problem of adequate management to reduce morbidity and the rate of recurrence. We report the cases of two male patients aged 45 and 57 years, who presented with perianal and buttock BLT for which large excisions were performed with satisfactory outcomes. We discuss the epidemiological and therapeutic aspects.