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Allostery in the dynamic coactivator domain KIX occurs through minor conformational micro-states

The coactivator KIX of CBP uses two binding surfaces to recognize multiple activators and exhibits allostery in ternary complex formation. Activator•coactivator interactions are central to transcriptional regulation, yet the microscopic origins of allostery in dynamic proteins like KIX are largely u...

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Detalles Bibliográficos
Autores principales:	Peiffer, Amanda L., Garlick, Julie M., Joy, Stephen T., Mapp, Anna K., Brooks, Charles L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067669/ https://www.ncbi.nlm.nih.gov/pubmed/35452454 http://dx.doi.org/10.1371/journal.pcbi.1009977

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