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Initial assessment of the spatial learning, reversal, and sequencing task capabilities of knock-in rats with humanizing mutations in the Aβ-coding region of App

Model organisms mimicking the pathogenesis of human diseases are useful for identifying pathogenic mechanisms and testing therapeutic efficacy of compounds targeting them. Models of Alzheimer’s disease (AD) and related dementias (ADRD) aim to reproduce the brain pathology associated with these neuro...

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Detalles Bibliográficos
Autores principales:	Pham, Hoa, Yin, Tao, D’Adamio, Luciano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067689/ https://www.ncbi.nlm.nih.gov/pubmed/35507596 http://dx.doi.org/10.1371/journal.pone.0263546

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