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Mechanistic basis for multidrug resistance and collateral drug sensitivity conferred to the malaria parasite by polymorphisms in PfMDR1 and PfCRT

Polymorphisms in the Plasmodium falciparum multidrug resistance protein 1 (pfmdr1) gene and the Plasmodium falciparum chloroquine resistance transporter (pfcrt) gene alter the malaria parasite’s susceptibility to most of the current antimalarial drugs. However, the precise mechanisms by which PfMDR1...

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Detalles Bibliográficos
Autores principales:	Shafik, Sarah Heckmatt, Richards, Sashika Natasha, Corry, Ben, Martin, Rowena Elizabeth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067703/ https://www.ncbi.nlm.nih.gov/pubmed/35507548 http://dx.doi.org/10.1371/journal.pbio.3001616

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