Abstract 158: Comparison of different screening tools for predicting osteoporosis in community dwelling post-menopausal women

Background: Dual-energy X-ray absorptiometry (DEXA) is gold standard in diagnosing osteoporosis. However, screening all postmenopausal women (PMW) for osteoporosis is not feasible in clinical practice. Questionaire based screening tools have still not been validated in Indian settings. Aims and Objectives: This cross-sectional study aimed to assess the performance of various osteoporosis-screening tools (OSTA, ORAI, SCORE, ABONE, BW, OSIRIS) in prediction of osteoporosis in PMW. Results: We enrolled 190 healthy middle-class community dwelling postmenopausal women (mean age 61.09 ± 6.5 years, range 50-86 years). The mean age of menopause was at 46.21 ± 4.9 years. Mean BMI was 27.92 ± 4.72 kg/m(2). Self reported fracture was present in 26.8% patients. BMD parameters showed osteoporosis in 63 (38.7%); osteopenia in 54 (33.1%) and normal in 46 patients (28.2%). Vitamin D deficiency (serum 25OHD <20 ng/ml) was present in majority (48.7%) of subjects. Clinically applicable screening tool for osteoporosis status were ABONE (AUC: 0.628) followed by the ORAI (AUC: 0.608, specificity 41%, Sensitivity- 97%). Conclusions: ABONE and ORAI clinical risk instruments demonstrate high sensitivity for predicting osteopororosis in PMW. These can help us identify individuals at high risk for osteoporosis and prioritize them for DEXA scanning.