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Abstract 158: Comparison of different screening tools for predicting osteoporosis in community dwelling post-menopausal women

Background: Dual-energy X-ray absorptiometry (DEXA) is gold standard in diagnosing osteoporosis. However, screening all postmenopausal women (PMW) for osteoporosis is not feasible in clinical practice. Questionaire based screening tools have still not been validated in Indian settings. Aims and Obje...

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Autores principales: Singhal, Vaibhav, Kakaji, Manisha, Awasthi, Ashish, Gupta, Sushil Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067712/
http://dx.doi.org/10.4103/2230-8210.342283
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author Singhal, Vaibhav
Kakaji, Manisha
Awasthi, Ashish
Gupta, Sushil Kumar
author_facet Singhal, Vaibhav
Kakaji, Manisha
Awasthi, Ashish
Gupta, Sushil Kumar
author_sort Singhal, Vaibhav
collection PubMed
description Background: Dual-energy X-ray absorptiometry (DEXA) is gold standard in diagnosing osteoporosis. However, screening all postmenopausal women (PMW) for osteoporosis is not feasible in clinical practice. Questionaire based screening tools have still not been validated in Indian settings. Aims and Objectives: This cross-sectional study aimed to assess the performance of various osteoporosis-screening tools (OSTA, ORAI, SCORE, ABONE, BW, OSIRIS) in prediction of osteoporosis in PMW. Results: We enrolled 190 healthy middle-class community dwelling postmenopausal women (mean age 61.09 ± 6.5 years, range 50-86 years). The mean age of menopause was at 46.21 ± 4.9 years. Mean BMI was 27.92 ± 4.72 kg/m(2). Self reported fracture was present in 26.8% patients. BMD parameters showed osteoporosis in 63 (38.7%); osteopenia in 54 (33.1%) and normal in 46 patients (28.2%). Vitamin D deficiency (serum 25OHD <20 ng/ml) was present in majority (48.7%) of subjects. Clinically applicable screening tool for osteoporosis status were ABONE (AUC: 0.628) followed by the ORAI (AUC: 0.608, specificity 41%, Sensitivity- 97%). Conclusions: ABONE and ORAI clinical risk instruments demonstrate high sensitivity for predicting osteopororosis in PMW. These can help us identify individuals at high risk for osteoporosis and prioritize them for DEXA scanning.
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spelling pubmed-90677122022-05-05 Abstract 158: Comparison of different screening tools for predicting osteoporosis in community dwelling post-menopausal women Singhal, Vaibhav Kakaji, Manisha Awasthi, Ashish Gupta, Sushil Kumar Indian J Endocrinol Metab Abstracts … Esicon 2021 Background: Dual-energy X-ray absorptiometry (DEXA) is gold standard in diagnosing osteoporosis. However, screening all postmenopausal women (PMW) for osteoporosis is not feasible in clinical practice. Questionaire based screening tools have still not been validated in Indian settings. Aims and Objectives: This cross-sectional study aimed to assess the performance of various osteoporosis-screening tools (OSTA, ORAI, SCORE, ABONE, BW, OSIRIS) in prediction of osteoporosis in PMW. Results: We enrolled 190 healthy middle-class community dwelling postmenopausal women (mean age 61.09 ± 6.5 years, range 50-86 years). The mean age of menopause was at 46.21 ± 4.9 years. Mean BMI was 27.92 ± 4.72 kg/m(2). Self reported fracture was present in 26.8% patients. BMD parameters showed osteoporosis in 63 (38.7%); osteopenia in 54 (33.1%) and normal in 46 patients (28.2%). Vitamin D deficiency (serum 25OHD <20 ng/ml) was present in majority (48.7%) of subjects. Clinically applicable screening tool for osteoporosis status were ABONE (AUC: 0.628) followed by the ORAI (AUC: 0.608, specificity 41%, Sensitivity- 97%). Conclusions: ABONE and ORAI clinical risk instruments demonstrate high sensitivity for predicting osteopororosis in PMW. These can help us identify individuals at high risk for osteoporosis and prioritize them for DEXA scanning. Wolters Kluwer - Medknow 2022-03 /pmc/articles/PMC9067712/ http://dx.doi.org/10.4103/2230-8210.342283 Text en Copyright: © 2022 Indian Journal of Endocrinology and Metabolism https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Abstracts … Esicon 2021
Singhal, Vaibhav
Kakaji, Manisha
Awasthi, Ashish
Gupta, Sushil Kumar
Abstract 158: Comparison of different screening tools for predicting osteoporosis in community dwelling post-menopausal women
title Abstract 158: Comparison of different screening tools for predicting osteoporosis in community dwelling post-menopausal women
title_full Abstract 158: Comparison of different screening tools for predicting osteoporosis in community dwelling post-menopausal women
title_fullStr Abstract 158: Comparison of different screening tools for predicting osteoporosis in community dwelling post-menopausal women
title_full_unstemmed Abstract 158: Comparison of different screening tools for predicting osteoporosis in community dwelling post-menopausal women
title_short Abstract 158: Comparison of different screening tools for predicting osteoporosis in community dwelling post-menopausal women
title_sort abstract 158: comparison of different screening tools for predicting osteoporosis in community dwelling post-menopausal women
topic Abstracts … Esicon 2021
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067712/
http://dx.doi.org/10.4103/2230-8210.342283
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