Abstract 121: EFT in subclinical hypothyroidism and its correlation with various parameters

Background: The Cardiometabolic risk associated with subclinical hypothyroidism (SCH) is well known in adults. However, there are few data available for children with SCH. Aims and Objective: To see Epicardial Fat Thickness (EFT) in Children with Subclinical Hypothyroidism and its correlation with subclinical atherosclerosis and various parameters. Materials and Methods: A total of 34 children with subclinical hypothyroidism presenting to the department of Endocrinology and Pediatrics were recruited. 39 healthy age and sex matched children were taken as control. They were screened for cardiometabolic parameters. Echocardiography was done for EFT and carotid intima media thickness (CIMT) was measured by noninvasive USG. Results: The mean age of cases and controls were 10.32±3.89 and 10.08±3.3 years respectively. A total 20 (58.8%) number of cases and 20 (51.3%) number of controls were males. The mean TSH of cases and control were 9.58±4.31 mIU/ml and 3.16±1.05 mIU/ml respectively. Compared to controls, the children with SCH had significantly higher TC (p=0.05) and LDL (p=0.03) as well as the cardiac risk ratio (LDL/HDL) (p=0.002). Further on Echocardiography, EFT (6.11±0.91 vs. 4.54±0.7, p<0.001) and CIMT (0.53±0.13 vs. 0.44±0.06, p<0.001) were significantly higher in cases as compared to controls. However, the EFT did not correlate with TSH or CIMT. Further, there was no difference in EFT and other parameters in patients who were TPO positive vs. negative (p>0.05). Conclusion: EFT and CIMT were significantly higher in SCH children. Measurement of EFT in children of SCH may identify the patients at risk of developing cardiovascular disease later in life.