Abstract 84: Clinical and aetiological spectrum of thyrotoxic patients: A multi-centre analysis

Background: Thyrotoxicosis may present with variety of symptoms and aetiologies. Its aetiology can be ascertained on the basis of history, clinical presentations, biochemistry and imaging, to manage thyrotoxicosis appropriately. Aims and objectives: To study clinical profile and aetiology among thyrotoxic patients. Results: We collected data of newly diagnosed thyrotoxic patients at 3 endocrinology clinics over 1 year (01/09/2016-31/08/2017). Total 263 patients were included in the study at New Delhi (109), Gurugram (99), Lucknow (55). Thyrotoxicosis was more common in females (70.8%) than males (29.2%). Thyroiditis (subacute 110, 85.9%, painless 9, 7% and postpartum 5, 3.9%) was present in 128 (48.7%) patients, 115 (43.7%) had Graves’ disease and 20 (7.6%) had nodular thyrotoxicosis (7 Solitary toxic nodule, 13 toxic multinodular goitre). Graves’ disease was most common cause of thyrotoxicosis in New Delhi (53.2%) and Lucknow (58.2%), while subacute thyroiditis in Gurugram (71.7%). Family history of thyroid disease was more prevalent in patients with Graves’ disease (48.7%) than nodular thyrotoxicosis (25%) and thyroiditis (11.7%). Thyrotoxicosis symptoms like excessive sweating (52.8%) and weight loss (47.7%) was more common with thyroiditis, while tremors (60.4%), diarrhea (56.5%), insomnia (50.9%), were more common with Graves’ disease. Conclusion: Graves’ disease and subacute thyroiditis constitute the majority of patients suffering from thyrotoxcosis. Proper clinical evaluation and investigations are key to manage these patients.