Abstract 133: Correlation of inflammatory markers with metabolic and hormonal parameters in first degree relatives of PCOS patients

Background: PCOS is a state of chronic low-grade inflammation. There is familial clustering of PCOS. Relatively few studies have investigated inflammatory markers in the first-degree relatives of PCOS patients. Aims and Objectives: The aim of the current study was to estimate the levels of inflammatory markers in first degree relatives of PCOS patient and its correlation with various Metabolic and Hormonal parameters. Results: Total 66 (41 female and 25 male) first degree relatives of PCOS patients were included. Mean age was 39.3±9.5 years. 22.7% of patient had normal BMI while 48.4% were overweight and 28.7% were obese. The mean hsCRP was 2.47±1.07 mg/L, IL-6 was 3.53±1.07 pg/ml and TWBC was 7.24 x 10(3)/ul. The mean hsCRP was >2 mg/L in all three BMI subgroups. There was significant positive correlation of LH with hsCRP (r=0.428, p<0.001), IL-6 (r=0.680, p<0.001) and TWBC (r=0.738, p<0.001) and significant negative correlation of SHBG levels with hsCRP (r= -0.325, p<0.001), IL-6 (r= -0.560, p<0.001) and TWBC (r= -0.465, p<0.001). There was no correlation of inflammatory markers with weight, BMI, waist circumference, SBP, DBP, FPG, LDL, HDL and HOMA IR. Conclusion: High mean hsCRP levels suggests that first degree relatives of PCOS patient are at increased risk of future CVD and the higher levels were independent of BMI category. There was significant correlation between the inflammatory markers and SHBG and LH levels but not with metabolic parameters. So, first degree relatives of PCOS patient have chronic low-grade inflammation.