Abstract 56: Clinical profile of adult onset hypopituitarism in patients presenting to a tertiary care center in South Tamil Nadu

Background: The data regarding clinical profile of adult onset hypopituitarism in India is limited. Previous studies have shown that pituitary and sellar tumors are the most common cause of hypopituitarism. Aims and Objectives: To study the clinical profile of patients with adult onset hypopituitarism presenting to the Endocrinology Department to our tertiary care centre. Results: A total of seventeen patients were included in the analyses. The mean age of the patients was 39.55 +/-14 years. There were 8 (47%) males and 9 (53%) females included in the study. The most common presenting complaints were amenorrhea (52%), headache (35%), visual complaints (29%). 29%(n=5) patients were admitted with acute adrenal crises requiring intravenous steroids at diagnosis. 11%(n=2) of patients had pituitary apoplexy. 47%(n=8) patients had pituitary or sellar tumors, 35%(n=6) patients had postpartum pituitary necrosis, one patient each had history of snake bite and head trauma. 94 %( n=16) patients had secondary adrenal insufficiency, 88 %( n=15) patients had secondary hypothyroidism, 70 %( n=12) patients had hypogonadotrophic hypogonadism, and only 11% (n=2) had growth hormone deficiency. 88 %( n=15) patients had panhypopituitarism. Conclusion: The most common causes of hypopituitarism in our study were pituitary and sellar tumors. 88% patients had panhypopituitarism, 35% patients had deficiency of two pituitary hormones.