Abstract 120: Prevalence of hypogonadism in men with type 2 diabetes mellitus and its association with insulin resistance, metabolic and clinical parameters

Background: Hypogonadism is commonly found in men with type 2 diabetes mellitus (T2DM). The inverse association between testosterone and insulin resistance is also reported. Aims and Objectives: To investigate the prevalence of hypogonadism in men with T2DM and to evaluate the association between hypogonadism with insulin resistance along with metabolic and clinical parameters. Methods: This is a cross sectional study of 257 consecutive men with T2DM. Hypogonadism is defined on the symptoms as defined in the androgen deficiency in aging male questionnaire (ADAM) along with low calculated testosterone levels (calculated by vermeulen equation taking total testosterone, albumin and sex hormone binding globulin). Insulin resistance is measured by HOMA-IR, QUICKI. Results: The overall prevalence of hypogonadism in our cohort was 11.67%. 86.67% patients had hypogonadotropic hypogonadism while rest were hypergonadotropic hypogonadism. There is a significant inverse correlation of fasting Insulin (r=-0.198, p<0.001), HOMA IR (r=-0.288, p<0.001) and BMI (r=0.139, p<0.001) with testosterone levels. On linear regression analysis, HOMA IR was independently associated with testosterone levels (odds ratio= -5.185; 95% CI= -8.29 -to -2.075) even after adjusting for age, BMI, HBA1c and lipid levels. Among chronic complications, only diabetic retinopathy was significantly associated with presence of hypogonadism. Conclusion: In our recruited population, hypogonadism was found in 11.67% of individuals. Markers of insulin resistance were independently associated with hypogonadism among T2DM men.