Abstract 12: Prediction of rise in alkaline phosphatase at different vitamin D levels

Background: Vitamin D deficiency with rickets and tetany are common in young infants in India. The data on vitamin D status of healthy term breastfed Indian infants and mothers are scant. In fact the correlation of Vitamin D deficiency and alkaline phosphatase (ALP) are inaccurate in many studies. Aim and Objective: To determine whether serum vitamin D levels are correlated with serum levels of alkaline phosphatase or not and to study the point at which ALP surge occurs in Vitamin D deficiency. Results: At 9 months out of 96 samples, 16 had mild Insufficient (≥15 – 20 ng/mL) (20.8%), 42 had moderate Deficient (<15 ng/mL) (54.5%) and 0 had severe Severe deficient (<5 ng/mL) vitamin D deficiencies. All of the patients in the three groups had alkaline phosphatase within normal limits and The ROC curve demonstrated that low vitamin D level is predicted by a high ALP cut off of ALP is 190.90 IU/L with reasonable sensitivity and specificity The correlation coefficient of alkaline phosphatase and serum vitamin D3 levels was r =0.501 (p =0.001). Conclusion: Serum vitamin D3 levels correlated well with increased serum alkaline phosphatase levels but the level at which the ALP surge occur was on lower side.