Abstract 68: Hypertriglyceridemia-induced acute pancreatitis – Experience from a single center of 20 patients

Background and Aim: Although hypertriglyceridemia (HTG) is a well-established cause of acute pancreatitis (AP), there are no clear-cut therapeutic guidelines. Furthermore, studies regarding treatment and outcome of hypertriglyceridemia-induced acute pancreatitis (HTGAP) in comparison to non-HTGAP are scarce. The present study was aimed to determine the frequency and outcome of HTGAP in comparison to non-HTGAP. Materials and Methods: All patients admitted with AP from January 2017 to August 2021 at St. John's Medical College Hospital, Bengaluru were included, and data were collected prospectively. Patients with HTGAP and non-HTGAP were compared. Results: Of 964 patients admitted with AP, 20 (2.12%, M: F -13:7) were HTG related. The mean age was 39.05 years and the mean triglyceride levels were 3620.8 mg/dl (range 1094 - 11,991). Patients with HTGAP in comparison to non- HTGAP had significantly (p <0.05) high BMI (29.22 v/s 25.69), high severity scores (BISAP and CT severity score, 2.6 v/s 2.06 and 7.5 v/s 4.80) and required prolonged hospitalization (12.9 v/s 6.5 days). 16 patients were treated with insulin infusion and rest conservatively. Conclusion: HTGAP occurred in young patients with high BMI and was associated with more severe disease and required prolonged hospitalization in comparison to patients with non-HTGAP.