Abstract 72: Prevalence, course, and predictive factors of water and electrolyte disturbances (WEDs) following transsphenoidal pituitary surgery (TSS) in patients with pituitary adenoma

Background: TSS is commonly associated with various WEDs in postoperative period, which can lead to prolonged hospital stay, readmission and rarely be life threatening. There is scarcity of prospective studies regarding various factors which could predict occurrence of these disturbances. Aims and Objectives: To prospectively study the prevalence, presentation and clinical course of WEDs following TSS in patients with pituitary adenoma and assess potential risk factors for these disturbances. Results: Forty patients (median age 45.5 years, 60% male) harbored 25 clinically hormone inactive and 15 hormone secreting pituitary adenoma. Postoperative WEDs occurred in 45 % of the patients; in 22.5 % as transient diabetes insipidus (DI) %, in 5 % as biphasic response, in 5% as isolated SIADH, in 12.5% as persistent DI. Median day of onset of DI was day 2 and remission was day 4. Median day of onset of SIADH was day 5 and remission was day 9. Younger age and greater adenoma volume were associated with increased risk of DI. Conclusion: WEDs are common following TSS. Diabetes insipidus was more common than SIADH.