Abstract 125: Tropical hypopitutarism – Single centre experience

Background: Etiology of hypopituitarism differs in tropical countries compared to the West and includes pituitary abscess, snake bite, HIV infection, Sheehan syndrome, road traffic accidents, iron overload states etc. Aims and Objectives: The present case series highlights the spectrum of hypopituitarism in tropical countries. Case Details: C1: 23 y/o female presented with loss of consciousness, unrecordable BP and hypoglycemia. H/O spontaneous pre term delivery at home with significant PPH with lactational failure. C2: 21 y/o male came with c/o poor height and weight gain and poor development of secondary sexual characteristics. Examination revealed a large healed scar over foot which developed after snake bite in past. C3: 41 y/o female with h/o recurrent episodes of altered sensorium. H/o PPH, lactational failure, amenorrhea following home delivery. C4: 30 y/o female presented with h/o delivery with PPH, followed by amenorrhea, lactation failure with sparse axillary, pubic hair. MRI pituitary was normal in C1 and showed empty sella for C2, C3 and C4. Conclusion: The etiology and clinical features of hypopituitarism are variable. Awareness and early recognition in these cases is necessary for optimal management of the patient.