Abstract 145: Etiological profile of precocious puberty: A JIPMER experience

Background: Precocious puberty (PP) is defined as the appearance of secondary sexual characteristics before 8 years in girls and 9 years in boys. The data on the etiological spectrum of precocious puberty from India is limited. Here, we present the analysis of retrospective data of children who presented with PP to the Department of Endocrinology, JIPMER from 2015 to 2021. Aims and Objectives: To describe the etiological profile of children presenting with PP. Results: A total of 26 children (16 girls) presented during this period with PP. 17 children presented with central PP (CPP). The median age of presentation was 6 years (range 2.5-8 years). The most common etiology for CPP was idiopathic CPP [n=7 (females-6)]) followed by congenital adrenal hyperplasia (CAH) with CPP (n=5) and hypothalamic hamartoma (n=3). One child developed CPP after surgery and radiotherapy for astrocytoma and another child developed CPP after surgery for Leydig cell tumour. 13 children had peripheral PP (PPP). The median age of presentation was 5 years (range 0.8-8 years). 2 cases each were due to adrenal neoplasms and gonadal neoplasms. 2 girls were diagnosed with Mccune Albright syndrome. 6 children (2 girls) had poorly controlled CAH with peripheral PP. 4 of them had progressed to central PP after optimising the GC medication. A girl was diagnosed with Van Wyk-Grumbach syndrome. Conclusion: We present here the retrospective data showing the etiological spectrum of precocious puberty from a tertiary medicare centre. The most common cause of CPP was idiopathic CPP whereas the most common cause of peripheral PP was CAH.