Abstract 42: B-Lymphocyte subset distribution in patients with hyperprolactinemia

Background: The PRL-R is a member of the GH/cytokine receptor super family which is also expressed on immune cells and activation modulates several cell functions such as differentiation, proliferation, survival, and secretion. Peripheral B-cell subset distribution and the serum autoantibody profile in women with HPRL are largely unknown. Aims and Objectives: The current study aimed to investigate B-lymphocyte subset distribution and the autoantibody prevalence in women with HPRL. Methods: Peripheral blood was collected from 30 women who had PRL>50ng/ml and from 24 healthy women who had normal PRL aged between 18-45. All were examined for prolactin, B-cell subsets were measured by flow cytometry, Anti-nuclear antibody (ANA), Rheumatoid factor, Anticardiolipin IgG, Immunoglobulin G, M&A, Anti-TPO, Anti-Tg. Results: The percentages of Plasmablast (p-0.015) among the total B cells from and Immunoglobulin IgA (p-0.012) in HPRL women were significantly higher than those from healthy women, while percentages of B-regulatory (p-0.003) and Mature cell (p<0.001) and Immunoglobulin M (p-0.012) were higher in healthy women. Conclusions: Women with HPRL had a higher prevalence of more Plasmablast cells and lower prevalence of B-regulatory cells than healthy women.