Abstract 131: Evaluation of left ventricular systolic function using global longitudinal strain by 2D speckle tracking echocardiography in patients with acromegaly

Background: Acromegaly is a rare disease resulting from Growth hormone excess. It is associated with an increased risk of cardiovascular mortality and morbidity. Global Longitudinal Strain (GLS) analysis by 2D Speckle tracking echocardiography (STE) offers a more sensitive assessment of myocardial contractility, which may help to identify patients with subclinical LV systolic dysfunction. We report a series of 10 subjects with Acromegaly comparing GLS using 2D STE and ejection fraction by the conventional method. Results: Ten subjects (Male=7, Female=3) with Acromegaly irrespective of their disease activity were included. The mean age was 44.1±7.6. All the subjects had normal ejection fraction, and the mean ejection fraction was 58±2.05%. STE revealed four subjects having abnormal GLS; two had mild, and two had moderately abnormal GLS values. The mean Left Ventricular Mass index was 87.92±23.64 g/m(2), and the mean Left Atrial Volume index was 23.2±3.73 ml/m(2). Conclusion: In spite of having normal left ventricular ejection fraction, GLS measured by STE were abnormal among four subjects indicating subclinical LV systolic dysfunction revealing decreased myocardial contractility. This study explores the potential application GLS by 2D STE in subjects with Acromegaly.