Characterization of a vaccine-elicited human antibody with sequence homology to VRC01-class antibodies that binds the C1C2 gp120 domain

Broadly HIV-1–neutralizing VRC01-class antibodies bind the CD4-binding site of Env and contain V(H)1-2*02–derived heavy chains paired with light chains expressing five–amino acid–long CDRL3s. Their unmutated germline forms do not recognize HIV-1 Env, and their lack of elicitation in human clinical t...

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Detalles Bibliográficos
Autores principales: Gray, Matthew D., Feng, Junli, Weidle, Connor E., Cohen, Kristen W., Ballweber-Fleming, Lamar, MacCamy, Anna J., Huynh, Crystal N., Trichka, Josephine J., Montefiori, David, Ferrari, Guido, Pancera, Marie, McElrath, M. Juliana, Stamatatos, Leonidas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067929/
https://www.ncbi.nlm.nih.gov/pubmed/35507661
http://dx.doi.org/10.1126/sciadv.abm3948

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