Cargando…

Evaluation of Mucosamin Effect on Treating Radiation Induced Oral Mucositis during and after Radiotherapy amongst Patients with Oral Cavity Squamous Cell Carcinoma

BACKGROUND: Oral mucositis is a serious complication radiation therapy for cancer. This is a major complication during radiation therapy of the head and neck tumors in approximately all patients. Therefore, this study was conducted to evaluate the effect of Mucosamin on treatment of radiation induce...

Descripción completa

Detalles Bibliográficos
Autores principales: Nasrollahi, Hamid, Khaki, Saeedeh, Ansari, Mansour, Ahmadloo, Niloofar, Khanjani, Nezhat, Hamedi, Sayed Hasan, Omidvari, Shapoor, Mosalaei, Ahmad, Mohammadianpanah, Mohammad, Kadkhodaei, Behnam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068180/
https://www.ncbi.nlm.nih.gov/pubmed/34837931
http://dx.doi.org/10.31557/APJCP.2021.22.11.3711
_version_ 1784700171131551744
author Nasrollahi, Hamid
Khaki, Saeedeh
Ansari, Mansour
Ahmadloo, Niloofar
Khanjani, Nezhat
Hamedi, Sayed Hasan
Omidvari, Shapoor
Mosalaei, Ahmad
Mohammadianpanah, Mohammad
Kadkhodaei, Behnam
author_facet Nasrollahi, Hamid
Khaki, Saeedeh
Ansari, Mansour
Ahmadloo, Niloofar
Khanjani, Nezhat
Hamedi, Sayed Hasan
Omidvari, Shapoor
Mosalaei, Ahmad
Mohammadianpanah, Mohammad
Kadkhodaei, Behnam
author_sort Nasrollahi, Hamid
collection PubMed
description BACKGROUND: Oral mucositis is a serious complication radiation therapy for cancer. This is a major complication during radiation therapy of the head and neck tumors in approximately all patients. Therefore, this study was conducted to evaluate the effect of Mucosamin on treatment of radiation induced oral mucositis during and after radiotherapy amongst patients with oral cavity squamous cell carcinoma. MATERIALS AND METHODS: In this prospective clinical trial, eligible patients who referred to radiation oncology department of Namazi Hospital, Shiraz, Iran from Jan 2018 till Jan 2019 were evaluated. The cases with confirmed pathologic diagnosis of squamous cell carcinoma of the oral cavity underwent 6,000 cGy radiation therapy and were randomly divided into two groups: 1- Intervention group; Mucosamin spray for 3-4 times a day (n = 40); 2 - Control group; standard medications (3 times a day) (n = 40). Oral mucositis was evaluated weekly based on RTOG scoring scale. Grade of mucositis was recorded during treatment and after radiation therapy. RESULTS: A total of 80 patients were divided in two groups of Mucosamin and control. From week 3 until the end of radiotherapy (week 6) and after radiotherapy (week 8), there was a significant difference in the severity of oral mucositis between the Mucosamin and the control groups (P <0.05). CONCLUSION: The results of this study showed that Mucosamin spray was able to significantly improved radiation-induced oral mucositis in patients with oral squamous cell carcinoma.
format Online
Article
Text
id pubmed-9068180
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher West Asia Organization for Cancer Prevention
record_format MEDLINE/PubMed
spelling pubmed-90681802022-05-06 Evaluation of Mucosamin Effect on Treating Radiation Induced Oral Mucositis during and after Radiotherapy amongst Patients with Oral Cavity Squamous Cell Carcinoma Nasrollahi, Hamid Khaki, Saeedeh Ansari, Mansour Ahmadloo, Niloofar Khanjani, Nezhat Hamedi, Sayed Hasan Omidvari, Shapoor Mosalaei, Ahmad Mohammadianpanah, Mohammad Kadkhodaei, Behnam Asian Pac J Cancer Prev Research Article BACKGROUND: Oral mucositis is a serious complication radiation therapy for cancer. This is a major complication during radiation therapy of the head and neck tumors in approximately all patients. Therefore, this study was conducted to evaluate the effect of Mucosamin on treatment of radiation induced oral mucositis during and after radiotherapy amongst patients with oral cavity squamous cell carcinoma. MATERIALS AND METHODS: In this prospective clinical trial, eligible patients who referred to radiation oncology department of Namazi Hospital, Shiraz, Iran from Jan 2018 till Jan 2019 were evaluated. The cases with confirmed pathologic diagnosis of squamous cell carcinoma of the oral cavity underwent 6,000 cGy radiation therapy and were randomly divided into two groups: 1- Intervention group; Mucosamin spray for 3-4 times a day (n = 40); 2 - Control group; standard medications (3 times a day) (n = 40). Oral mucositis was evaluated weekly based on RTOG scoring scale. Grade of mucositis was recorded during treatment and after radiation therapy. RESULTS: A total of 80 patients were divided in two groups of Mucosamin and control. From week 3 until the end of radiotherapy (week 6) and after radiotherapy (week 8), there was a significant difference in the severity of oral mucositis between the Mucosamin and the control groups (P <0.05). CONCLUSION: The results of this study showed that Mucosamin spray was able to significantly improved radiation-induced oral mucositis in patients with oral squamous cell carcinoma. West Asia Organization for Cancer Prevention 2021-11 /pmc/articles/PMC9068180/ /pubmed/34837931 http://dx.doi.org/10.31557/APJCP.2021.22.11.3711 Text en https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Nasrollahi, Hamid
Khaki, Saeedeh
Ansari, Mansour
Ahmadloo, Niloofar
Khanjani, Nezhat
Hamedi, Sayed Hasan
Omidvari, Shapoor
Mosalaei, Ahmad
Mohammadianpanah, Mohammad
Kadkhodaei, Behnam
Evaluation of Mucosamin Effect on Treating Radiation Induced Oral Mucositis during and after Radiotherapy amongst Patients with Oral Cavity Squamous Cell Carcinoma
title Evaluation of Mucosamin Effect on Treating Radiation Induced Oral Mucositis during and after Radiotherapy amongst Patients with Oral Cavity Squamous Cell Carcinoma
title_full Evaluation of Mucosamin Effect on Treating Radiation Induced Oral Mucositis during and after Radiotherapy amongst Patients with Oral Cavity Squamous Cell Carcinoma
title_fullStr Evaluation of Mucosamin Effect on Treating Radiation Induced Oral Mucositis during and after Radiotherapy amongst Patients with Oral Cavity Squamous Cell Carcinoma
title_full_unstemmed Evaluation of Mucosamin Effect on Treating Radiation Induced Oral Mucositis during and after Radiotherapy amongst Patients with Oral Cavity Squamous Cell Carcinoma
title_short Evaluation of Mucosamin Effect on Treating Radiation Induced Oral Mucositis during and after Radiotherapy amongst Patients with Oral Cavity Squamous Cell Carcinoma
title_sort evaluation of mucosamin effect on treating radiation induced oral mucositis during and after radiotherapy amongst patients with oral cavity squamous cell carcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068180/
https://www.ncbi.nlm.nih.gov/pubmed/34837931
http://dx.doi.org/10.31557/APJCP.2021.22.11.3711
work_keys_str_mv AT nasrollahihamid evaluationofmucosamineffectontreatingradiationinducedoralmucositisduringandafterradiotherapyamongstpatientswithoralcavitysquamouscellcarcinoma
AT khakisaeedeh evaluationofmucosamineffectontreatingradiationinducedoralmucositisduringandafterradiotherapyamongstpatientswithoralcavitysquamouscellcarcinoma
AT ansarimansour evaluationofmucosamineffectontreatingradiationinducedoralmucositisduringandafterradiotherapyamongstpatientswithoralcavitysquamouscellcarcinoma
AT ahmadlooniloofar evaluationofmucosamineffectontreatingradiationinducedoralmucositisduringandafterradiotherapyamongstpatientswithoralcavitysquamouscellcarcinoma
AT khanjaninezhat evaluationofmucosamineffectontreatingradiationinducedoralmucositisduringandafterradiotherapyamongstpatientswithoralcavitysquamouscellcarcinoma
AT hamedisayedhasan evaluationofmucosamineffectontreatingradiationinducedoralmucositisduringandafterradiotherapyamongstpatientswithoralcavitysquamouscellcarcinoma
AT omidvarishapoor evaluationofmucosamineffectontreatingradiationinducedoralmucositisduringandafterradiotherapyamongstpatientswithoralcavitysquamouscellcarcinoma
AT mosalaeiahmad evaluationofmucosamineffectontreatingradiationinducedoralmucositisduringandafterradiotherapyamongstpatientswithoralcavitysquamouscellcarcinoma
AT mohammadianpanahmohammad evaluationofmucosamineffectontreatingradiationinducedoralmucositisduringandafterradiotherapyamongstpatientswithoralcavitysquamouscellcarcinoma
AT kadkhodaeibehnam evaluationofmucosamineffectontreatingradiationinducedoralmucositisduringandafterradiotherapyamongstpatientswithoralcavitysquamouscellcarcinoma