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De novo-designed transmembrane domains tune engineered receptor functions

De novo-designed receptor transmembrane domains (TMDs) present opportunities for precise control of cellular receptor functions. We developed a de novo design strategy for generating programmed membrane proteins (proMPs): single-pass α-helical TMDs that self-assemble through computationally defined...

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Detalles Bibliográficos
Autores principales:	Elazar, Assaf, Chandler, Nicholas J, Davey, Ashleigh S, Weinstein, Jonathan Y, Nguyen, Julie V, Trenker, Raphael, Cross, Ryan S, Jenkins, Misty R, Call, Melissa J, Call, Matthew E, Fleishman, Sarel J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Immunology and Inflammation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068223/ https://www.ncbi.nlm.nih.gov/pubmed/35506657 http://dx.doi.org/10.7554/eLife.75660

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