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Using fecal immunochemical test values below conventional cut-off to individualize colorectal cancer screening
Background and study aims Of the participants in the Danish screening program, 89.9 % to 92.5 % have fecal immunochemical test (FIT) values < 10 μg/g feces (equivalent to 50 ng hemoglobin/mL buffer). This study aimed to investigate the risk of interval colorectal cancer (CRC) in this group befor...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Georg Thieme Verlag KG
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068275/ https://www.ncbi.nlm.nih.gov/pubmed/35528219 http://dx.doi.org/10.1055/a-1743-2651 |
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author | Plantener, Eva Deding, Ulrik Madsen, Jeppe Buur Kroijer, Rasmus Madsen, Jonna Skov Baatrup, Gunnar |
author_facet | Plantener, Eva Deding, Ulrik Madsen, Jeppe Buur Kroijer, Rasmus Madsen, Jonna Skov Baatrup, Gunnar |
author_sort | Plantener, Eva |
collection | PubMed |
description | Background and study aims Of the participants in the Danish screening program, 89.9 % to 92.5 % have fecal immunochemical test (FIT) values < 10 μg/g feces (equivalent to 50 ng hemoglobin/mL buffer). This study aimed to investigate the risk of interval colorectal cancer (CRC) in this group before the next biennial screening round. Patients and methods This cohort study included all citizens from the region of Southern Denmark who participated in the Danish bowel screening program from 2014 trough 2016 and had a FIT value < 10 μg/g feces. Individuals receiving a CRC diagnosis were identified through the national CRC registry, with a follow up of 2 years corresponding to the current screening interval. We also examined the 3-year CRC incidence. Hazard ratios (HRs) were estimated using univariate and multivariate Cox proportional hazard regression models. Results Data from 185,654 citizens presenting with a FIT value < 10 μg/g feces were eligible for analysis. Overall, interval CRC incidence was 0.07 % within 2 years with HRs of 4.16 (95 % confidence interval [CI] 2.67;6.48) and 5.8 (95 % CI 3.34;10.05) for FIT values of 4 to 6.9 μg/g feces and 7 to 9.9 μg/g feces, respectively, compared to those having a FIT value below the limit of quantification of 4 μg/g feces. After 3 years, the overall CRC incidence increased to 0.14 %; however, this was not significant. Conclusions This study demonstrates a positive correlation between FIT value and risk of interval cancer even for very low values. It further suggests that an increase in the screening interval could be reasonable in the low FIT categories. |
format | Online Article Text |
id | pubmed-9068275 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Georg Thieme Verlag KG |
record_format | MEDLINE/PubMed |
spelling | pubmed-90682752022-05-05 Using fecal immunochemical test values below conventional cut-off to individualize colorectal cancer screening Plantener, Eva Deding, Ulrik Madsen, Jeppe Buur Kroijer, Rasmus Madsen, Jonna Skov Baatrup, Gunnar Endosc Int Open Background and study aims Of the participants in the Danish screening program, 89.9 % to 92.5 % have fecal immunochemical test (FIT) values < 10 μg/g feces (equivalent to 50 ng hemoglobin/mL buffer). This study aimed to investigate the risk of interval colorectal cancer (CRC) in this group before the next biennial screening round. Patients and methods This cohort study included all citizens from the region of Southern Denmark who participated in the Danish bowel screening program from 2014 trough 2016 and had a FIT value < 10 μg/g feces. Individuals receiving a CRC diagnosis were identified through the national CRC registry, with a follow up of 2 years corresponding to the current screening interval. We also examined the 3-year CRC incidence. Hazard ratios (HRs) were estimated using univariate and multivariate Cox proportional hazard regression models. Results Data from 185,654 citizens presenting with a FIT value < 10 μg/g feces were eligible for analysis. Overall, interval CRC incidence was 0.07 % within 2 years with HRs of 4.16 (95 % confidence interval [CI] 2.67;6.48) and 5.8 (95 % CI 3.34;10.05) for FIT values of 4 to 6.9 μg/g feces and 7 to 9.9 μg/g feces, respectively, compared to those having a FIT value below the limit of quantification of 4 μg/g feces. After 3 years, the overall CRC incidence increased to 0.14 %; however, this was not significant. Conclusions This study demonstrates a positive correlation between FIT value and risk of interval cancer even for very low values. It further suggests that an increase in the screening interval could be reasonable in the low FIT categories. Georg Thieme Verlag KG 2022-04-14 /pmc/articles/PMC9068275/ /pubmed/35528219 http://dx.doi.org/10.1055/a-1743-2651 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited. |
spellingShingle | Plantener, Eva Deding, Ulrik Madsen, Jeppe Buur Kroijer, Rasmus Madsen, Jonna Skov Baatrup, Gunnar Using fecal immunochemical test values below conventional cut-off to individualize colorectal cancer screening |
title | Using fecal immunochemical test values below conventional cut-off to individualize colorectal cancer screening |
title_full | Using fecal immunochemical test values below conventional cut-off to individualize colorectal cancer screening |
title_fullStr | Using fecal immunochemical test values below conventional cut-off to individualize colorectal cancer screening |
title_full_unstemmed | Using fecal immunochemical test values below conventional cut-off to individualize colorectal cancer screening |
title_short | Using fecal immunochemical test values below conventional cut-off to individualize colorectal cancer screening |
title_sort | using fecal immunochemical test values below conventional cut-off to individualize colorectal cancer screening |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068275/ https://www.ncbi.nlm.nih.gov/pubmed/35528219 http://dx.doi.org/10.1055/a-1743-2651 |
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