Cargando…
Reduning Injection versus Neuraminidase Inhibitors in the Treatment of Influenza: A Systematic Review and Meta-Analysis
OBJECTIVE: To perform a systematic review to assess the effectiveness and safety of Reduning Injection versus neuraminidase inhibitors in treatment of influenza. METHODS: The MEDLINE, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), Chinese Bio-medical Literature and Retrieval S...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Nature Singapore
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068505/ https://www.ncbi.nlm.nih.gov/pubmed/35508864 http://dx.doi.org/10.1007/s11655-022-3524-9 |
_version_ | 1784700233829056512 |
---|---|
author | Zhao, Guo-zhen Li, Bo Wang, Ya-fan Guo, Shi-qi Du, Yuan Ma, Qiu-xiao Guo, Yu-hong Liu, Qing-quan |
author_facet | Zhao, Guo-zhen Li, Bo Wang, Ya-fan Guo, Shi-qi Du, Yuan Ma, Qiu-xiao Guo, Yu-hong Liu, Qing-quan |
author_sort | Zhao, Guo-zhen |
collection | PubMed |
description | OBJECTIVE: To perform a systematic review to assess the effectiveness and safety of Reduning Injection versus neuraminidase inhibitors in treatment of influenza. METHODS: The MEDLINE, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), Chinese Bio-medical Literature and Retrieval System (Sinomed), China National Knowledge Infrastructure Database (CNKI), China Science and Technology Journal Database (VIP), Wanfang Data Knowledge Service Platform and ClinicalTrails.gov were systematically searched from inception dates to May 2021 for randomized controlled trials (RCTs) exploring Reduning Injection alone or in combination with neuraminidase inhibitors in patients with influenza. Statistical analysis was performed using RevMan 5.4 and Stata 15.1. The qualities of the involved studies were assessed by the risk of bias according to the Cochrane handbook. The evidence quality of each outcome was evaluated by GRADEpro GDT. RESULTS: Twelve trials with 1,460 patients were included. The included studies had a certain unclear or high risk of bias. Reduning Injection appeared to be more effective in shortening the fever clearance time (MD: −16.20 h, 95% CI: −19.40 to −12.99, 7 trials, 814 patients, I(2)=94%, very low certainty), fever alleviation time (MD: −4.09 h, 95% CI: −4.22 to −3.96, 3 trials, 366 patients, I(2)=0%, low certainty), cough alleviation time (MD: −21.34 h, 95% CI: −41.56 to −1.11, 2 trials, 228 patients, I(2)=89%, very low certainty), fatigue alleviation time (MD: −31.83 h, 95% CI: −36.88 to −26.77, 2 trials, 270 patients, I(2)=0%, low certainty), sore throat alleviation time (MD: −28.66 h, 95% CI: −32.23 to −25.10, 1 trial, 150 patients, low certainty), and improving the total effective rate (RR: 1.15, 95% CI: 1.06 to 1.25, 10 trials, 1,074 patients, I(2)=76%, very low certainty). Besides, Reduning Injection seemed generally safe. CONCLUSIONS: This study provided low or very low evidence indicating Reduning Injection may be effective in the treatment of influenza and might be safe. Further rigorously designed studies are needed to confirm the effectiveness and safety of Reduning Injection and support it as a recommendation for influenza. ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material (Appendixes 1 and 2) are available in the online version of this article at DOI: 10.1007/s11655-022-3524-9. |
format | Online Article Text |
id | pubmed-9068505 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Nature Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-90685052022-05-04 Reduning Injection versus Neuraminidase Inhibitors in the Treatment of Influenza: A Systematic Review and Meta-Analysis Zhao, Guo-zhen Li, Bo Wang, Ya-fan Guo, Shi-qi Du, Yuan Ma, Qiu-xiao Guo, Yu-hong Liu, Qing-quan Chin J Integr Med Evidence-Based Integrative Medicine OBJECTIVE: To perform a systematic review to assess the effectiveness and safety of Reduning Injection versus neuraminidase inhibitors in treatment of influenza. METHODS: The MEDLINE, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), Chinese Bio-medical Literature and Retrieval System (Sinomed), China National Knowledge Infrastructure Database (CNKI), China Science and Technology Journal Database (VIP), Wanfang Data Knowledge Service Platform and ClinicalTrails.gov were systematically searched from inception dates to May 2021 for randomized controlled trials (RCTs) exploring Reduning Injection alone or in combination with neuraminidase inhibitors in patients with influenza. Statistical analysis was performed using RevMan 5.4 and Stata 15.1. The qualities of the involved studies were assessed by the risk of bias according to the Cochrane handbook. The evidence quality of each outcome was evaluated by GRADEpro GDT. RESULTS: Twelve trials with 1,460 patients were included. The included studies had a certain unclear or high risk of bias. Reduning Injection appeared to be more effective in shortening the fever clearance time (MD: −16.20 h, 95% CI: −19.40 to −12.99, 7 trials, 814 patients, I(2)=94%, very low certainty), fever alleviation time (MD: −4.09 h, 95% CI: −4.22 to −3.96, 3 trials, 366 patients, I(2)=0%, low certainty), cough alleviation time (MD: −21.34 h, 95% CI: −41.56 to −1.11, 2 trials, 228 patients, I(2)=89%, very low certainty), fatigue alleviation time (MD: −31.83 h, 95% CI: −36.88 to −26.77, 2 trials, 270 patients, I(2)=0%, low certainty), sore throat alleviation time (MD: −28.66 h, 95% CI: −32.23 to −25.10, 1 trial, 150 patients, low certainty), and improving the total effective rate (RR: 1.15, 95% CI: 1.06 to 1.25, 10 trials, 1,074 patients, I(2)=76%, very low certainty). Besides, Reduning Injection seemed generally safe. CONCLUSIONS: This study provided low or very low evidence indicating Reduning Injection may be effective in the treatment of influenza and might be safe. Further rigorously designed studies are needed to confirm the effectiveness and safety of Reduning Injection and support it as a recommendation for influenza. ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material (Appendixes 1 and 2) are available in the online version of this article at DOI: 10.1007/s11655-022-3524-9. Springer Nature Singapore 2022-05-04 2022 /pmc/articles/PMC9068505/ /pubmed/35508864 http://dx.doi.org/10.1007/s11655-022-3524-9 Text en © The Chinese Journal of Integrated Traditional and Western Medicine Press and Springer-Verlag GmbH Germany, part of Springer Nature 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Evidence-Based Integrative Medicine Zhao, Guo-zhen Li, Bo Wang, Ya-fan Guo, Shi-qi Du, Yuan Ma, Qiu-xiao Guo, Yu-hong Liu, Qing-quan Reduning Injection versus Neuraminidase Inhibitors in the Treatment of Influenza: A Systematic Review and Meta-Analysis |
title | Reduning Injection versus Neuraminidase Inhibitors in the Treatment of Influenza: A Systematic Review and Meta-Analysis |
title_full | Reduning Injection versus Neuraminidase Inhibitors in the Treatment of Influenza: A Systematic Review and Meta-Analysis |
title_fullStr | Reduning Injection versus Neuraminidase Inhibitors in the Treatment of Influenza: A Systematic Review and Meta-Analysis |
title_full_unstemmed | Reduning Injection versus Neuraminidase Inhibitors in the Treatment of Influenza: A Systematic Review and Meta-Analysis |
title_short | Reduning Injection versus Neuraminidase Inhibitors in the Treatment of Influenza: A Systematic Review and Meta-Analysis |
title_sort | reduning injection versus neuraminidase inhibitors in the treatment of influenza: a systematic review and meta-analysis |
topic | Evidence-Based Integrative Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068505/ https://www.ncbi.nlm.nih.gov/pubmed/35508864 http://dx.doi.org/10.1007/s11655-022-3524-9 |
work_keys_str_mv | AT zhaoguozhen reduninginjectionversusneuraminidaseinhibitorsinthetreatmentofinfluenzaasystematicreviewandmetaanalysis AT libo reduninginjectionversusneuraminidaseinhibitorsinthetreatmentofinfluenzaasystematicreviewandmetaanalysis AT wangyafan reduninginjectionversusneuraminidaseinhibitorsinthetreatmentofinfluenzaasystematicreviewandmetaanalysis AT guoshiqi reduninginjectionversusneuraminidaseinhibitorsinthetreatmentofinfluenzaasystematicreviewandmetaanalysis AT duyuan reduninginjectionversusneuraminidaseinhibitorsinthetreatmentofinfluenzaasystematicreviewandmetaanalysis AT maqiuxiao reduninginjectionversusneuraminidaseinhibitorsinthetreatmentofinfluenzaasystematicreviewandmetaanalysis AT guoyuhong reduninginjectionversusneuraminidaseinhibitorsinthetreatmentofinfluenzaasystematicreviewandmetaanalysis AT liuqingquan reduninginjectionversusneuraminidaseinhibitorsinthetreatmentofinfluenzaasystematicreviewandmetaanalysis |