Germline rare variants of lectin pathway genes predispose to asymptomatic SARS-CoV-2 infection in elderly individuals

PURPOSE: Emerging evidence suggest that infection-dependent hyperactivation of complement system (CS) may worsen COVID-19 outcome. We investigated the role of predicted high impact rare variants — referred as qualifying variants (QVs) — of CS genes in predisposing asymptomatic COVID-19 in elderly in...

Descripción completa

Detalles Bibliográficos
Autores principales: D’Alterio, Giuseppe, Lasorsa, Vito Alessandro, Bonfiglio, Ferdinando, Cantalupo, Sueva, Rosato, Barbara Eleni, Andolfo, Immacolata, Russo, Roberta, Esposito, Umberto, Frisso, Giulia, Abete, Pasquale, Cassese, Gian Marco, Servillo, Giuseppe, Gentile, Ivan, Piscopo, Carmelo, Della Monica, Matteo, Fiorentino, Giuseppe, Boccia, Angelo, Paolella, Giovanni, Ferrucci, Veronica, de Antonellis, Pasqualino, Siciliano, Roberto, Asadzadeh, Fathem, Cerino, Pellegrino, Buonerba, Carlo, Pierri, Biancamaria, Zollo, Massimo, Iolascon, Achille, Capasso, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Inc. on behalf of American College of Medical Genetics and Genomics. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068606/
https://www.ncbi.nlm.nih.gov/pubmed/35511137
http://dx.doi.org/10.1016/j.gim.2022.04.007

Ejemplares similares

Ejemplares similares