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The mechanism of activation of MEK1 by B-Raf and KSR1

MEK1 interactions with B-Raf and KSR1 are key steps in Ras/Raf/MEK/ERK signaling. Despite this, vital mechanistic details of how these execute signal transduction are still enigmatic. Among these is why, despite B-Raf and KSR1 kinase domains similarity, the B-Raf/MEK1 and KSR1/MEK1 complexes have di...

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Detalles Bibliográficos
Autores principales:	Maloney, Ryan C., Zhang, Mingzhen, Liu, Yonglan, Jang, Hyunbum, Nussinov, Ruth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068654/ https://www.ncbi.nlm.nih.gov/pubmed/35508574 http://dx.doi.org/10.1007/s00018-022-04296-0

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