Identification of DAXX as a restriction factor of SARS-CoV-2 through a CRISPR/Cas9 screen

Interferon restricts SARS-CoV-2 replication in cell culture, but only a handful of Interferon Stimulated Genes with antiviral activity against SARS-CoV-2 have been identified. Here, we describe a functional CRISPR/Cas9 screen aiming at identifying SARS-CoV-2 restriction factors. We identify DAXX, a...

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Detalles Bibliográficos
Autores principales: Mac Kain, Alice, Maarifi, Ghizlane, Aicher, Sophie-Marie, Arhel, Nathalie, Baidaliuk, Artem, Munier, Sandie, Donati, Flora, Vallet, Thomas, Tran, Quang Dinh, Hardy, Alexandra, Chazal, Maxime, Porrot, Françoise, OhAinle, Molly, Carlson-Stevermer, Jared, Oki, Jennifer, Holden, Kevin, Zimmer, Gert, Simon-Lorière, Etienne, Bruel, Timothée, Schwartz, Olivier, van der Werf, Sylvie, Jouvenet, Nolwenn, Nisole, Sébastien, Vignuzzi, Marco, Roesch, Ferdinand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068693/
https://www.ncbi.nlm.nih.gov/pubmed/35508460
http://dx.doi.org/10.1038/s41467-022-30134-9

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