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Determination of unbound piperaquine in human plasma by ultra-high performance liquid chromatography tandem mass spectrometry

Piperaquine (PQ) is an antimalarial drug that is highly protein-bound. Variation in plasma protein contents may affect the pharmacokinetic (PK) exposure of unbound drug, leading to alteration of clinical outcomes. All published methods for determination of PQ in human plasma measure the total PQ inc...

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Detalles Bibliográficos
Autores principales:	Huang, Liusheng, Sok, Vong, Aslam-Mir, Usman, Marzan, Florence, Whalen, Meghan, Rosenthal, Philip J., Aweeka, Francesca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068709/ https://www.ncbi.nlm.nih.gov/pubmed/35531322 http://dx.doi.org/10.1016/j.jcoa.2022.100042

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