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The EORTC QLU-C10D discrete choice experiment for cancer patients: a first step towards patient utility weights

BACKGROUND: The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Utility-Core 10 Dimensions (QLU-C10D) is a novel cancer-specific preference-based measure (PBM) for which value sets are being developed for an increasing number of countries. This is done by obtaining...

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Autores principales: Gamper, Eva-Maria, King, Madeleine T., Norman, Richard, Loth, Fanny L. C., Holzner, Bernhard, Kemmler, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068836/
https://www.ncbi.nlm.nih.gov/pubmed/35507194
http://dx.doi.org/10.1186/s41687-022-00430-5
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author Gamper, Eva-Maria
King, Madeleine T.
Norman, Richard
Loth, Fanny L. C.
Holzner, Bernhard
Kemmler, Georg
author_facet Gamper, Eva-Maria
King, Madeleine T.
Norman, Richard
Loth, Fanny L. C.
Holzner, Bernhard
Kemmler, Georg
author_sort Gamper, Eva-Maria
collection PubMed
description BACKGROUND: The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Utility-Core 10 Dimensions (QLU-C10D) is a novel cancer-specific preference-based measure (PBM) for which value sets are being developed for an increasing number of countries. This is done by obtaining health preferences from the respective general population. There is an ongoing discussion if instead patients suffering from the disease in question should be asked for their preferences. We used the QLU-C10D valuation survey, originally designed for use in the general population, in a sample of cancer patients in Austria to assess the methodology’s acceptability and applicability in this target group before obtaining QLU-C10D patient preferences. METHODS: The core of the QLU-C10D valuation survey is a discrete choice experiment in which respondents are asked to give preferences for certain health states (described by a relatively large number of 10 quality of life domains) and an associated survival time. They therewith are asked to trade off quality of life against life time. As this might be a very burdensome task for cancer patients undergoing treatment, a cognitive interview was conducted in a pilot sample to assess burden and potential additional needs for explanation in order to be able to use the DCE for the development of QLU-C10D patient preferences. In addition, responses to general feedback questions on the survey were compared against responses from a matched control group from the already completed Austrian general population valuation survey. RESULTS: We included 48 patients (mean age 59.9 years; 46% female). In the cognitive interview, the majority indicated that their experience with the survey was positive (85%) and overall clarity as good (90%). In response to the general feedback questions, patients rated the presentation of the health states less clear than matched controls (p = 0.008). There was no difference between patients and the general population concerning the difficulty in choosing between the health states (p = 0.344). CONCLUSION: Despite the relatively large number of DCE domains the survey was manageable for patients and allows going on with the QLU-C10D patient valuation study. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s41687-022-00430-5.
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spelling pubmed-90688362022-05-07 The EORTC QLU-C10D discrete choice experiment for cancer patients: a first step towards patient utility weights Gamper, Eva-Maria King, Madeleine T. Norman, Richard Loth, Fanny L. C. Holzner, Bernhard Kemmler, Georg J Patient Rep Outcomes Research BACKGROUND: The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Utility-Core 10 Dimensions (QLU-C10D) is a novel cancer-specific preference-based measure (PBM) for which value sets are being developed for an increasing number of countries. This is done by obtaining health preferences from the respective general population. There is an ongoing discussion if instead patients suffering from the disease in question should be asked for their preferences. We used the QLU-C10D valuation survey, originally designed for use in the general population, in a sample of cancer patients in Austria to assess the methodology’s acceptability and applicability in this target group before obtaining QLU-C10D patient preferences. METHODS: The core of the QLU-C10D valuation survey is a discrete choice experiment in which respondents are asked to give preferences for certain health states (described by a relatively large number of 10 quality of life domains) and an associated survival time. They therewith are asked to trade off quality of life against life time. As this might be a very burdensome task for cancer patients undergoing treatment, a cognitive interview was conducted in a pilot sample to assess burden and potential additional needs for explanation in order to be able to use the DCE for the development of QLU-C10D patient preferences. In addition, responses to general feedback questions on the survey were compared against responses from a matched control group from the already completed Austrian general population valuation survey. RESULTS: We included 48 patients (mean age 59.9 years; 46% female). In the cognitive interview, the majority indicated that their experience with the survey was positive (85%) and overall clarity as good (90%). In response to the general feedback questions, patients rated the presentation of the health states less clear than matched controls (p = 0.008). There was no difference between patients and the general population concerning the difficulty in choosing between the health states (p = 0.344). CONCLUSION: Despite the relatively large number of DCE domains the survey was manageable for patients and allows going on with the QLU-C10D patient valuation study. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s41687-022-00430-5. Springer International Publishing 2022-05-04 /pmc/articles/PMC9068836/ /pubmed/35507194 http://dx.doi.org/10.1186/s41687-022-00430-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research
Gamper, Eva-Maria
King, Madeleine T.
Norman, Richard
Loth, Fanny L. C.
Holzner, Bernhard
Kemmler, Georg
The EORTC QLU-C10D discrete choice experiment for cancer patients: a first step towards patient utility weights
title The EORTC QLU-C10D discrete choice experiment for cancer patients: a first step towards patient utility weights
title_full The EORTC QLU-C10D discrete choice experiment for cancer patients: a first step towards patient utility weights
title_fullStr The EORTC QLU-C10D discrete choice experiment for cancer patients: a first step towards patient utility weights
title_full_unstemmed The EORTC QLU-C10D discrete choice experiment for cancer patients: a first step towards patient utility weights
title_short The EORTC QLU-C10D discrete choice experiment for cancer patients: a first step towards patient utility weights
title_sort eortc qlu-c10d discrete choice experiment for cancer patients: a first step towards patient utility weights
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068836/
https://www.ncbi.nlm.nih.gov/pubmed/35507194
http://dx.doi.org/10.1186/s41687-022-00430-5
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