First crystal structures of 1-deoxy-d-xylulose 5-phosphate synthase (DXPS) from Mycobacterium tuberculosis indicate a distinct mechanism of intermediate stabilization

The development of drug resistance by Mycobacterium tuberculosis and other pathogenic bacteria emphasizes the need for new antibiotics. Unlike animals, most bacteria synthesize isoprenoid precursors through the MEP pathway. 1-Deoxy-d-xylulose 5-phosphate synthase (DXPS) catalyzes the first reaction...

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Detalles Bibliográficos
Autores principales: Gierse, Robin M., Oerlemans, Rick, Reddem, Eswar R., Gawriljuk, Victor O., Alhayek, Alaa, Baitinger, Dominik, Jakobi, Harald, Laber, Bernd, Lange, Gudrun, Hirsch, Anna K. H., Groves, Matthew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068908/
https://www.ncbi.nlm.nih.gov/pubmed/35508530
http://dx.doi.org/10.1038/s41598-022-11205-9

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