Lung-Protective Ventilation Attenuates Mechanical Injury While Hypercapnia Attenuates Biological Injury in a Rat Model of Ventilator-Associated Lung Injury

Background and Objective: Lung-protective mechanical ventilation is known to attenuate ventilator-associated lung injury (VALI), but often at the expense of hypoventilation and hypercapnia. It remains unclear whether the main mechanism by which VALI is attenuated is a product of limiting mechanical...

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Detalles Bibliográficos
Autores principales: Ismaiel, Nada, Whynot, Sara, Geldenhuys, Laurette, Xu, Zhaolin, Slutsky, Arthur S., Chappe, Valerie, Henzler, Dietrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068936/
https://www.ncbi.nlm.nih.gov/pubmed/35530505
http://dx.doi.org/10.3389/fphys.2022.814968

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