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Differential Expression of E2F Transcription Factors and Their Functional and Prognostic Roles in Human Prostate Cancer

Given the tumor heterogeneity, most of the current prognostic indicators cannot accurately evaluate the prognosis of patients with prostate cancer, and thus, the best opportunity to intervene in the progression of this disease is missed. E2F transcription factors (E2Fs) have been reported to be invo...

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Autores principales: Han, Zhaodong, Mo, Rujun, Cai, Shanghua, Feng, Yuanfa, Tang, Zhenfeng, Ye, Jianheng, Liu, Ren, Cai, Zhiduan, Zhu, Xuejin, Deng, Yulin, Zou, Zhihao, Wu, Yongding, Cai, Zhouda, Liang, Yuxiang, Zhong, Weide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068940/
https://www.ncbi.nlm.nih.gov/pubmed/35531101
http://dx.doi.org/10.3389/fcell.2022.831329
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author Han, Zhaodong
Mo, Rujun
Cai, Shanghua
Feng, Yuanfa
Tang, Zhenfeng
Ye, Jianheng
Liu, Ren
Cai, Zhiduan
Zhu, Xuejin
Deng, Yulin
Zou, Zhihao
Wu, Yongding
Cai, Zhouda
Liang, Yuxiang
Zhong, Weide
author_facet Han, Zhaodong
Mo, Rujun
Cai, Shanghua
Feng, Yuanfa
Tang, Zhenfeng
Ye, Jianheng
Liu, Ren
Cai, Zhiduan
Zhu, Xuejin
Deng, Yulin
Zou, Zhihao
Wu, Yongding
Cai, Zhouda
Liang, Yuxiang
Zhong, Weide
author_sort Han, Zhaodong
collection PubMed
description Given the tumor heterogeneity, most of the current prognostic indicators cannot accurately evaluate the prognosis of patients with prostate cancer, and thus, the best opportunity to intervene in the progression of this disease is missed. E2F transcription factors (E2Fs) have been reported to be involved in the growth of various cancers. Accumulating studies indicate that prostate cancer (PCa) carcinogenesis is attributed to aberrant E2F expression or E2F alteration. However, the expression patterns and prognostic value of the eight E2Fs in prostate cancer have yet to be explored. In this study, The Cancer Genome Atlas (TCGA), Kaplan–Meier Plotter, Metascape, the Kyoto Encyclopedia of Genes and Genomes (KEGG), CIBERSORT, and cBioPortal and bioinformatic analysis were used to investigate E2Fs in patients with PCa. Our results showed that the expression of E2F1–3, E2F5, and E2F6 was higher in prostate cancer tissues than in benign tissues. Furthermore, elevated E2F1–3 and E2F5 expression levels were associated with a higher Gleason score (GS), advanced tumor stage, and metastasis. Survival analysis suggested that high transcription levels of E2F1–3, E2F5, E2F6, and E2F8 were associated with a higher risk of biochemical recurrence. In addition, we developed a prognostic model combining E2F1, E2F6, Gleason score, and the clinical stage that may accurately predict a biochemical recurrence-free survival. Functional enrichment analysis revealed that the E2F family members and their neighboring genes were mainly enriched in cell cycle-related pathways. Somatic mutations in different subgroups were also investigated, and immune components were predicted. Further experiments are warranted to clarify the biological associations between Pca-related E2F family genes, which may influence prognosis via the cell cycle pathway.
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spelling pubmed-90689402022-05-05 Differential Expression of E2F Transcription Factors and Their Functional and Prognostic Roles in Human Prostate Cancer Han, Zhaodong Mo, Rujun Cai, Shanghua Feng, Yuanfa Tang, Zhenfeng Ye, Jianheng Liu, Ren Cai, Zhiduan Zhu, Xuejin Deng, Yulin Zou, Zhihao Wu, Yongding Cai, Zhouda Liang, Yuxiang Zhong, Weide Front Cell Dev Biol Cell and Developmental Biology Given the tumor heterogeneity, most of the current prognostic indicators cannot accurately evaluate the prognosis of patients with prostate cancer, and thus, the best opportunity to intervene in the progression of this disease is missed. E2F transcription factors (E2Fs) have been reported to be involved in the growth of various cancers. Accumulating studies indicate that prostate cancer (PCa) carcinogenesis is attributed to aberrant E2F expression or E2F alteration. However, the expression patterns and prognostic value of the eight E2Fs in prostate cancer have yet to be explored. In this study, The Cancer Genome Atlas (TCGA), Kaplan–Meier Plotter, Metascape, the Kyoto Encyclopedia of Genes and Genomes (KEGG), CIBERSORT, and cBioPortal and bioinformatic analysis were used to investigate E2Fs in patients with PCa. Our results showed that the expression of E2F1–3, E2F5, and E2F6 was higher in prostate cancer tissues than in benign tissues. Furthermore, elevated E2F1–3 and E2F5 expression levels were associated with a higher Gleason score (GS), advanced tumor stage, and metastasis. Survival analysis suggested that high transcription levels of E2F1–3, E2F5, E2F6, and E2F8 were associated with a higher risk of biochemical recurrence. In addition, we developed a prognostic model combining E2F1, E2F6, Gleason score, and the clinical stage that may accurately predict a biochemical recurrence-free survival. Functional enrichment analysis revealed that the E2F family members and their neighboring genes were mainly enriched in cell cycle-related pathways. Somatic mutations in different subgroups were also investigated, and immune components were predicted. Further experiments are warranted to clarify the biological associations between Pca-related E2F family genes, which may influence prognosis via the cell cycle pathway. Frontiers Media S.A. 2022-04-21 /pmc/articles/PMC9068940/ /pubmed/35531101 http://dx.doi.org/10.3389/fcell.2022.831329 Text en Copyright © 2022 Han, Mo, Cai, Feng, Tang, Ye, Liu, Cai, Zhu, Deng, Zou, Wu, Cai, Liang and Zhong. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Han, Zhaodong
Mo, Rujun
Cai, Shanghua
Feng, Yuanfa
Tang, Zhenfeng
Ye, Jianheng
Liu, Ren
Cai, Zhiduan
Zhu, Xuejin
Deng, Yulin
Zou, Zhihao
Wu, Yongding
Cai, Zhouda
Liang, Yuxiang
Zhong, Weide
Differential Expression of E2F Transcription Factors and Their Functional and Prognostic Roles in Human Prostate Cancer
title Differential Expression of E2F Transcription Factors and Their Functional and Prognostic Roles in Human Prostate Cancer
title_full Differential Expression of E2F Transcription Factors and Their Functional and Prognostic Roles in Human Prostate Cancer
title_fullStr Differential Expression of E2F Transcription Factors and Their Functional and Prognostic Roles in Human Prostate Cancer
title_full_unstemmed Differential Expression of E2F Transcription Factors and Their Functional and Prognostic Roles in Human Prostate Cancer
title_short Differential Expression of E2F Transcription Factors and Their Functional and Prognostic Roles in Human Prostate Cancer
title_sort differential expression of e2f transcription factors and their functional and prognostic roles in human prostate cancer
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068940/
https://www.ncbi.nlm.nih.gov/pubmed/35531101
http://dx.doi.org/10.3389/fcell.2022.831329
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