Chukranoids A–I, isopimarane diterpenoids from Chukrasia velutina

Bioactivity guided separation of Chukrasia velutina root methanolic extract led to the isolation of nine new isopimarane diterpenoids, chukranoids A–I (1–9). The absolute configuration was then assigned by comparing the experimental CD spectra and the calculated CD spectra. Chukranoids A–I (1–9) sho...

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Detalles Bibliográficos
Autores principales: Nugroho, Alfarius Eko, Tange, Masaki, Kusakabe, Sumi, Hirasawa, Yusuke, Shirota, Osamu, Matsuno, Michiyo, Mizukami, Hajime, Tougan, Takahiro, Horii, Toshihiro, Morita, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9069220/
https://www.ncbi.nlm.nih.gov/pubmed/35511335
http://dx.doi.org/10.1007/s11418-022-01623-4
Descripción
Sumario:Bioactivity guided separation of Chukrasia velutina root methanolic extract led to the isolation of nine new isopimarane diterpenoids, chukranoids A–I (1–9). The absolute configuration was then assigned by comparing the experimental CD spectra and the calculated CD spectra. Chukranoids A–I (1–9) showed moderate antimalarial activity against Plasmodium falciparum 3D7 strain. It seems that conjugate system in the isopimarane skeleton may influence their antimalarial activity. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11418-022-01623-4.

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