Chukranoids A–I, isopimarane diterpenoids from Chukrasia velutina

Bioactivity guided separation of Chukrasia velutina root methanolic extract led to the isolation of nine new isopimarane diterpenoids, chukranoids A–I (1–9). The absolute configuration was then assigned by comparing the experimental CD spectra and the calculated CD spectra. Chukranoids A–I (1–9) sho...

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Autores principales: Nugroho, Alfarius Eko, Tange, Masaki, Kusakabe, Sumi, Hirasawa, Yusuke, Shirota, Osamu, Matsuno, Michiyo, Mizukami, Hajime, Tougan, Takahiro, Horii, Toshihiro, Morita, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9069220/
https://www.ncbi.nlm.nih.gov/pubmed/35511335
http://dx.doi.org/10.1007/s11418-022-01623-4
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author Nugroho, Alfarius Eko
Tange, Masaki
Kusakabe, Sumi
Hirasawa, Yusuke
Shirota, Osamu
Matsuno, Michiyo
Mizukami, Hajime
Tougan, Takahiro
Horii, Toshihiro
Morita, Hiroshi
author_facet Nugroho, Alfarius Eko
Tange, Masaki
Kusakabe, Sumi
Hirasawa, Yusuke
Shirota, Osamu
Matsuno, Michiyo
Mizukami, Hajime
Tougan, Takahiro
Horii, Toshihiro
Morita, Hiroshi
author_sort Nugroho, Alfarius Eko
collection PubMed
description Bioactivity guided separation of Chukrasia velutina root methanolic extract led to the isolation of nine new isopimarane diterpenoids, chukranoids A–I (1–9). The absolute configuration was then assigned by comparing the experimental CD spectra and the calculated CD spectra. Chukranoids A–I (1–9) showed moderate antimalarial activity against Plasmodium falciparum 3D7 strain. It seems that conjugate system in the isopimarane skeleton may influence their antimalarial activity. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11418-022-01623-4.
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spelling pubmed-90692202022-05-04 Chukranoids A–I, isopimarane diterpenoids from Chukrasia velutina Nugroho, Alfarius Eko Tange, Masaki Kusakabe, Sumi Hirasawa, Yusuke Shirota, Osamu Matsuno, Michiyo Mizukami, Hajime Tougan, Takahiro Horii, Toshihiro Morita, Hiroshi J Nat Med Original Paper Bioactivity guided separation of Chukrasia velutina root methanolic extract led to the isolation of nine new isopimarane diterpenoids, chukranoids A–I (1–9). The absolute configuration was then assigned by comparing the experimental CD spectra and the calculated CD spectra. Chukranoids A–I (1–9) showed moderate antimalarial activity against Plasmodium falciparum 3D7 strain. It seems that conjugate system in the isopimarane skeleton may influence their antimalarial activity. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11418-022-01623-4. Springer Nature Singapore 2022-05-05 2022 /pmc/articles/PMC9069220/ /pubmed/35511335 http://dx.doi.org/10.1007/s11418-022-01623-4 Text en © The Author(s) under exclusive licence to The Japanese Society of Pharmacognosy 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Paper
Nugroho, Alfarius Eko
Tange, Masaki
Kusakabe, Sumi
Hirasawa, Yusuke
Shirota, Osamu
Matsuno, Michiyo
Mizukami, Hajime
Tougan, Takahiro
Horii, Toshihiro
Morita, Hiroshi
Chukranoids A–I, isopimarane diterpenoids from Chukrasia velutina
title Chukranoids A–I, isopimarane diterpenoids from Chukrasia velutina
title_full Chukranoids A–I, isopimarane diterpenoids from Chukrasia velutina
title_fullStr Chukranoids A–I, isopimarane diterpenoids from Chukrasia velutina
title_full_unstemmed Chukranoids A–I, isopimarane diterpenoids from Chukrasia velutina
title_short Chukranoids A–I, isopimarane diterpenoids from Chukrasia velutina
title_sort chukranoids a–i, isopimarane diterpenoids from chukrasia velutina
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9069220/
https://www.ncbi.nlm.nih.gov/pubmed/35511335
http://dx.doi.org/10.1007/s11418-022-01623-4
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