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Low Carbohydrate Diets for Diabetic Cardiomyopathy: A Hypothesis

Elevated blood glucose levels, insulin resistance (IR), hyperinsulinemia and dyslipidemia the key aspects of type 2 diabetes mellitus (T2DM), contribute to the development of a certain form of cardiomyopathy. This cardiomyopathy, also known as diabetic cardiomyopathy (DMCM), typically occurs in the...

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Autores principales: Kleissl-Muir, Sabine, Rasmussen, Bodil, Owen, Alice, Zinn, Caryn, Driscoll, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9069235/
https://www.ncbi.nlm.nih.gov/pubmed/35529461
http://dx.doi.org/10.3389/fnut.2022.865489
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author Kleissl-Muir, Sabine
Rasmussen, Bodil
Owen, Alice
Zinn, Caryn
Driscoll, Andrea
author_facet Kleissl-Muir, Sabine
Rasmussen, Bodil
Owen, Alice
Zinn, Caryn
Driscoll, Andrea
author_sort Kleissl-Muir, Sabine
collection PubMed
description Elevated blood glucose levels, insulin resistance (IR), hyperinsulinemia and dyslipidemia the key aspects of type 2 diabetes mellitus (T2DM), contribute to the development of a certain form of cardiomyopathy. This cardiomyopathy, also known as diabetic cardiomyopathy (DMCM), typically occurs in the absence of overt coronary artery disease (CAD), hypertension or valvular disease. DMCM encompasses a variety of pathophysiological processes impacting the myocardium, hence increasing the risk for heart failure (HF) and significantly worsening outcomes in this population. Low fat (LF), calorie-restricted diets have been suggested as the preferred eating pattern for patients with HF. However, LF diets are naturally higher in carbohydrates (CHO). We argue that in an insulin resistant state, such as in DMCM, LF diets may worsen glycaemic control and promote further insulin resistance (IR), contributing to a physiological and functional decline in DMCM. We postulate that CHO restriction targeting hyperinsulinemia may be able to improve tissue and systemic IR. In recent years low carbohydrate diets (LC) including ketogenic diets (KD), have emerged as a safe and effective tool for the management of various clinical conditions such as T2DM and other metabolic disorders. CHO restriction achieves sustained glycaemic control, lower insulin levels and successfully reverses IR. In addition to this, its pleiotropic effects may present a metabolic stress defense and facilitate improvement to cardiac function in patients with HF. We therefore hypothesize that patients who adopt a LC diet may require less medications and experience improvements in HF-related symptom burden.
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spelling pubmed-90692352022-05-05 Low Carbohydrate Diets for Diabetic Cardiomyopathy: A Hypothesis Kleissl-Muir, Sabine Rasmussen, Bodil Owen, Alice Zinn, Caryn Driscoll, Andrea Front Nutr Nutrition Elevated blood glucose levels, insulin resistance (IR), hyperinsulinemia and dyslipidemia the key aspects of type 2 diabetes mellitus (T2DM), contribute to the development of a certain form of cardiomyopathy. This cardiomyopathy, also known as diabetic cardiomyopathy (DMCM), typically occurs in the absence of overt coronary artery disease (CAD), hypertension or valvular disease. DMCM encompasses a variety of pathophysiological processes impacting the myocardium, hence increasing the risk for heart failure (HF) and significantly worsening outcomes in this population. Low fat (LF), calorie-restricted diets have been suggested as the preferred eating pattern for patients with HF. However, LF diets are naturally higher in carbohydrates (CHO). We argue that in an insulin resistant state, such as in DMCM, LF diets may worsen glycaemic control and promote further insulin resistance (IR), contributing to a physiological and functional decline in DMCM. We postulate that CHO restriction targeting hyperinsulinemia may be able to improve tissue and systemic IR. In recent years low carbohydrate diets (LC) including ketogenic diets (KD), have emerged as a safe and effective tool for the management of various clinical conditions such as T2DM and other metabolic disorders. CHO restriction achieves sustained glycaemic control, lower insulin levels and successfully reverses IR. In addition to this, its pleiotropic effects may present a metabolic stress defense and facilitate improvement to cardiac function in patients with HF. We therefore hypothesize that patients who adopt a LC diet may require less medications and experience improvements in HF-related symptom burden. Frontiers Media S.A. 2022-04-20 /pmc/articles/PMC9069235/ /pubmed/35529461 http://dx.doi.org/10.3389/fnut.2022.865489 Text en Copyright © 2022 Kleissl-Muir, Rasmussen, Owen, Zinn and Driscoll. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Kleissl-Muir, Sabine
Rasmussen, Bodil
Owen, Alice
Zinn, Caryn
Driscoll, Andrea
Low Carbohydrate Diets for Diabetic Cardiomyopathy: A Hypothesis
title Low Carbohydrate Diets for Diabetic Cardiomyopathy: A Hypothesis
title_full Low Carbohydrate Diets for Diabetic Cardiomyopathy: A Hypothesis
title_fullStr Low Carbohydrate Diets for Diabetic Cardiomyopathy: A Hypothesis
title_full_unstemmed Low Carbohydrate Diets for Diabetic Cardiomyopathy: A Hypothesis
title_short Low Carbohydrate Diets for Diabetic Cardiomyopathy: A Hypothesis
title_sort low carbohydrate diets for diabetic cardiomyopathy: a hypothesis
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9069235/
https://www.ncbi.nlm.nih.gov/pubmed/35529461
http://dx.doi.org/10.3389/fnut.2022.865489
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