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Gather wisdom to overcome barriers: Well-designed nano-drug delivery systems for treating gliomas
Due to the special physiological and pathological characteristics of gliomas, most therapeutic drugs are prevented from entering the brain. To improve the poor prognosis of existing therapies, researchers have been continuously developing non-invasive methods to overcome barriers to gliomas therapy....
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9069319/ https://www.ncbi.nlm.nih.gov/pubmed/35530155 http://dx.doi.org/10.1016/j.apsb.2021.08.013 |
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author | Cui, Jiwei Xu, Yuanxin Tu, Haiyan Zhao, Huacong Wang, Honglan Di, Liuqing Wang, Ruoning |
author_facet | Cui, Jiwei Xu, Yuanxin Tu, Haiyan Zhao, Huacong Wang, Honglan Di, Liuqing Wang, Ruoning |
author_sort | Cui, Jiwei |
collection | PubMed |
description | Due to the special physiological and pathological characteristics of gliomas, most therapeutic drugs are prevented from entering the brain. To improve the poor prognosis of existing therapies, researchers have been continuously developing non-invasive methods to overcome barriers to gliomas therapy. Although these strategies can be used clinically to overcome the blood‒brain barrier (BBB), the accurate delivery of drugs to the glioma lesions cannot be ensured. Nano-drug delivery systems (NDDS) have been widely used for precise drug delivery. In recent years, researchers have gathered their wisdom to overcome barriers, so many well-designed NDDS have performed prominently in preclinical studies. These meticulous designs mainly include cascade passing through BBB and targeting to glioma lesions, drug release in response to the glioma microenvironment, biomimetic delivery systems based on endogenous cells/extracellular vesicles/protein, and carriers created according to the active ingredients of traditional Chinese medicines. We reviewed these well-designed NDDS in detail. Furthermore, we discussed the current ongoing and completed clinical trials of NDDS for gliomas therapy, and analyzed the challenges and trends faced by clinical translation of these well-designed NDDS. |
format | Online Article Text |
id | pubmed-9069319 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-90693192022-05-05 Gather wisdom to overcome barriers: Well-designed nano-drug delivery systems for treating gliomas Cui, Jiwei Xu, Yuanxin Tu, Haiyan Zhao, Huacong Wang, Honglan Di, Liuqing Wang, Ruoning Acta Pharm Sin B Review Due to the special physiological and pathological characteristics of gliomas, most therapeutic drugs are prevented from entering the brain. To improve the poor prognosis of existing therapies, researchers have been continuously developing non-invasive methods to overcome barriers to gliomas therapy. Although these strategies can be used clinically to overcome the blood‒brain barrier (BBB), the accurate delivery of drugs to the glioma lesions cannot be ensured. Nano-drug delivery systems (NDDS) have been widely used for precise drug delivery. In recent years, researchers have gathered their wisdom to overcome barriers, so many well-designed NDDS have performed prominently in preclinical studies. These meticulous designs mainly include cascade passing through BBB and targeting to glioma lesions, drug release in response to the glioma microenvironment, biomimetic delivery systems based on endogenous cells/extracellular vesicles/protein, and carriers created according to the active ingredients of traditional Chinese medicines. We reviewed these well-designed NDDS in detail. Furthermore, we discussed the current ongoing and completed clinical trials of NDDS for gliomas therapy, and analyzed the challenges and trends faced by clinical translation of these well-designed NDDS. Elsevier 2022-03 2021-08-14 /pmc/articles/PMC9069319/ /pubmed/35530155 http://dx.doi.org/10.1016/j.apsb.2021.08.013 Text en © 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Cui, Jiwei Xu, Yuanxin Tu, Haiyan Zhao, Huacong Wang, Honglan Di, Liuqing Wang, Ruoning Gather wisdom to overcome barriers: Well-designed nano-drug delivery systems for treating gliomas |
title | Gather wisdom to overcome barriers: Well-designed nano-drug delivery systems for treating gliomas |
title_full | Gather wisdom to overcome barriers: Well-designed nano-drug delivery systems for treating gliomas |
title_fullStr | Gather wisdom to overcome barriers: Well-designed nano-drug delivery systems for treating gliomas |
title_full_unstemmed | Gather wisdom to overcome barriers: Well-designed nano-drug delivery systems for treating gliomas |
title_short | Gather wisdom to overcome barriers: Well-designed nano-drug delivery systems for treating gliomas |
title_sort | gather wisdom to overcome barriers: well-designed nano-drug delivery systems for treating gliomas |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9069319/ https://www.ncbi.nlm.nih.gov/pubmed/35530155 http://dx.doi.org/10.1016/j.apsb.2021.08.013 |
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