circREEP3 Drives Colorectal Cancer Progression via Activation of FKBP10 Transcription and Restriction of Antitumor Immunity

Colorectal cancer (CRC) is one of the most common tumors around the world. Circular RNA is widely involved in tumor progression via unclear mechanisms. Here, circREEP3 is found to be upregulated in CRC tissues. circREEP3 upregulation predicts poor patient survival. circREEP3 knockout suppresses CRC...

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Autores principales: Chen, Zhenzhen, He, Luyun, Zhao, Liangbo, Zhang, Guangtan, Wang, Zhiwei, Zhu, Pingping, Liu, Benyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9069384/
https://www.ncbi.nlm.nih.gov/pubmed/35233964
http://dx.doi.org/10.1002/advs.202105160
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author Chen, Zhenzhen
He, Luyun
Zhao, Liangbo
Zhang, Guangtan
Wang, Zhiwei
Zhu, Pingping
Liu, Benyu
author_facet Chen, Zhenzhen
He, Luyun
Zhao, Liangbo
Zhang, Guangtan
Wang, Zhiwei
Zhu, Pingping
Liu, Benyu
author_sort Chen, Zhenzhen
collection PubMed
description Colorectal cancer (CRC) is one of the most common tumors around the world. Circular RNA is widely involved in tumor progression via unclear mechanisms. Here, circREEP3 is found to be upregulated in CRC tissues. circREEP3 upregulation predicts poor patient survival. circREEP3 knockout suppresses CRC tumorigenesis and metastasis, and impairs stem cell‐like phenotype. Mechanistically, circREEP3 recruits the chromatin remodeling protein CHD7 to FKBP10 promoter and activates its transcription. Moreover, circREEP3 restricts RIG‐1‐dependent antitumor immunity. FKBP10 is highly expressed in CRC tissues and associated with poor prognosis. FKBP10 ectopic expression partially rescues the potential of proliferation and metastasis in circREEP3‐deficient CRC cells. Thus, the findings support circREEP3‐FKBP10 axis drives CRC progression and may be a critical prognostic marker.
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spelling pubmed-90693842022-05-09 circREEP3 Drives Colorectal Cancer Progression via Activation of FKBP10 Transcription and Restriction of Antitumor Immunity Chen, Zhenzhen He, Luyun Zhao, Liangbo Zhang, Guangtan Wang, Zhiwei Zhu, Pingping Liu, Benyu Adv Sci (Weinh) Research Articles Colorectal cancer (CRC) is one of the most common tumors around the world. Circular RNA is widely involved in tumor progression via unclear mechanisms. Here, circREEP3 is found to be upregulated in CRC tissues. circREEP3 upregulation predicts poor patient survival. circREEP3 knockout suppresses CRC tumorigenesis and metastasis, and impairs stem cell‐like phenotype. Mechanistically, circREEP3 recruits the chromatin remodeling protein CHD7 to FKBP10 promoter and activates its transcription. Moreover, circREEP3 restricts RIG‐1‐dependent antitumor immunity. FKBP10 is highly expressed in CRC tissues and associated with poor prognosis. FKBP10 ectopic expression partially rescues the potential of proliferation and metastasis in circREEP3‐deficient CRC cells. Thus, the findings support circREEP3‐FKBP10 axis drives CRC progression and may be a critical prognostic marker. John Wiley and Sons Inc. 2022-03-01 /pmc/articles/PMC9069384/ /pubmed/35233964 http://dx.doi.org/10.1002/advs.202105160 Text en © 2022 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Chen, Zhenzhen
He, Luyun
Zhao, Liangbo
Zhang, Guangtan
Wang, Zhiwei
Zhu, Pingping
Liu, Benyu
circREEP3 Drives Colorectal Cancer Progression via Activation of FKBP10 Transcription and Restriction of Antitumor Immunity
title circREEP3 Drives Colorectal Cancer Progression via Activation of FKBP10 Transcription and Restriction of Antitumor Immunity
title_full circREEP3 Drives Colorectal Cancer Progression via Activation of FKBP10 Transcription and Restriction of Antitumor Immunity
title_fullStr circREEP3 Drives Colorectal Cancer Progression via Activation of FKBP10 Transcription and Restriction of Antitumor Immunity
title_full_unstemmed circREEP3 Drives Colorectal Cancer Progression via Activation of FKBP10 Transcription and Restriction of Antitumor Immunity
title_short circREEP3 Drives Colorectal Cancer Progression via Activation of FKBP10 Transcription and Restriction of Antitumor Immunity
title_sort circreep3 drives colorectal cancer progression via activation of fkbp10 transcription and restriction of antitumor immunity
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9069384/
https://www.ncbi.nlm.nih.gov/pubmed/35233964
http://dx.doi.org/10.1002/advs.202105160
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