Impairment of the autophagy–lysosomal pathway in Alzheimer's diseases: Pathogenic mechanisms and therapeutic potential

Alzheimer's disease (AD), the most common neurodegenerative disorder, is characterized by memory loss and cognitive dysfunction. The accumulation of misfolded protein aggregates including amyloid beta (Aβ) peptides and microtubule associated protein tau (MAPT/tau) in neuronal cells are hallmark...

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Detalles Bibliográficos
Autores principales: Zhang, Wei, Xu, Chengchao, Sun, Jichao, Shen, Han-Ming, Wang, Jigang, Yang, Chuanbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9069408/
https://www.ncbi.nlm.nih.gov/pubmed/35530153
http://dx.doi.org/10.1016/j.apsb.2022.01.008

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