Inhibiting DNA methylation alleviates cisplatin-induced hearing loss by decreasing oxidative stress-induced mitochondria-dependent apoptosis via the LRP1–PI3K/AKT pathway

Cisplatin-related ototoxicity is a critical side effect of chemotherapy and can lead to irreversible hearing loss. This study aimed to assess the potential effect of the DNA methyltransferase (DNMT) inhibitor RG108 on cisplatin-induced ototoxicity. Immunohistochemistry, apoptosis assay, and auditory...

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Detalles Bibliográficos
Autores principales: He, Yingzi, Zheng, Zhiwei, Liu, Chang, Li, Wen, Zhao, Liping, Nie, Guohui, Li, Huawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9069410/
https://www.ncbi.nlm.nih.gov/pubmed/35530135
http://dx.doi.org/10.1016/j.apsb.2021.11.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9069410/
https://www.ncbi.nlm.nih.gov/pubmed/35530135
http://dx.doi.org/10.1016/j.apsb.2021.11.002

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