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Network Pharmacology with Experimental Investigation of the Mechanisms of Rhizoma Polygonati against Prostate Cancer with Additional Herbzymatic Activity

[Image: see text] A combination therapy of RhizomaPolygonati (RP) with goji (Lycium chinense) has earned a long history in the prescriptions to promote male health. However, the mechanisms at both molecular and nanoscale quantum levels are unclear. Here, we found that processed RP extract induces ap...

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Autores principales: Kazybay, Bexultan, Sun, Qinglei, Dukenbayev, Kanat, Nurkesh, Ayan Amantaiuly, Xu, Na, Kutzhanova, Aidana, Razbekova, Madina, Kabylda, Anar, Yang, Qing, Wang, Qian, Ma, Cuiping, Xie, Yingqiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9069460/
https://www.ncbi.nlm.nih.gov/pubmed/35531567
http://dx.doi.org/10.1021/acsomega.1c03018
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author Kazybay, Bexultan
Sun, Qinglei
Dukenbayev, Kanat
Nurkesh, Ayan Amantaiuly
Xu, Na
Kutzhanova, Aidana
Razbekova, Madina
Kabylda, Anar
Yang, Qing
Wang, Qian
Ma, Cuiping
Xie, Yingqiu
author_facet Kazybay, Bexultan
Sun, Qinglei
Dukenbayev, Kanat
Nurkesh, Ayan Amantaiuly
Xu, Na
Kutzhanova, Aidana
Razbekova, Madina
Kabylda, Anar
Yang, Qing
Wang, Qian
Ma, Cuiping
Xie, Yingqiu
author_sort Kazybay, Bexultan
collection PubMed
description [Image: see text] A combination therapy of RhizomaPolygonati (RP) with goji (Lycium chinense) has earned a long history in the prescriptions to promote male health. However, the mechanisms at both molecular and nanoscale quantum levels are unclear. Here, we found that processed RP extract induces apoptosis and cell cycle arrest in cancer cells, thereby inhibiting prostate cancer cell proliferation enhanced by processed goji extract associated with an augment of the nanoscale herbzyme of phosphatase. For network pharmacology analysis, RP-induced PI3K-AKT pathways are essential for both benign prostatic hyperplasia and prostate cancer, and the RP/goji combination induces potent pathways which include androgen and estrogen response, kinase regulation, apoptosis, and prostate cancer singling. In addition, the experimental investigation showed that the prostate cancer cells are sensitive to RP extract for inhibiting colony formation. Finally, the natural compound baicalein found in RP ingredients showed a linked activity of top-ranked signaling targets of kinases including MAPK, AKT, and EGFR by the database of cMAP and HERB. Thus, both the nanozyme and ingredients might contribute to the RP in anti-prostate cancer which can be enhanced by goji extract. The proposed nanoscale RP extract might be of significance in developing novel anti-prostate cancer agents by combining goji compositions and targeted therapy compounds.
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spelling pubmed-90694602022-05-06 Network Pharmacology with Experimental Investigation of the Mechanisms of Rhizoma Polygonati against Prostate Cancer with Additional Herbzymatic Activity Kazybay, Bexultan Sun, Qinglei Dukenbayev, Kanat Nurkesh, Ayan Amantaiuly Xu, Na Kutzhanova, Aidana Razbekova, Madina Kabylda, Anar Yang, Qing Wang, Qian Ma, Cuiping Xie, Yingqiu ACS Omega [Image: see text] A combination therapy of RhizomaPolygonati (RP) with goji (Lycium chinense) has earned a long history in the prescriptions to promote male health. However, the mechanisms at both molecular and nanoscale quantum levels are unclear. Here, we found that processed RP extract induces apoptosis and cell cycle arrest in cancer cells, thereby inhibiting prostate cancer cell proliferation enhanced by processed goji extract associated with an augment of the nanoscale herbzyme of phosphatase. For network pharmacology analysis, RP-induced PI3K-AKT pathways are essential for both benign prostatic hyperplasia and prostate cancer, and the RP/goji combination induces potent pathways which include androgen and estrogen response, kinase regulation, apoptosis, and prostate cancer singling. In addition, the experimental investigation showed that the prostate cancer cells are sensitive to RP extract for inhibiting colony formation. Finally, the natural compound baicalein found in RP ingredients showed a linked activity of top-ranked signaling targets of kinases including MAPK, AKT, and EGFR by the database of cMAP and HERB. Thus, both the nanozyme and ingredients might contribute to the RP in anti-prostate cancer which can be enhanced by goji extract. The proposed nanoscale RP extract might be of significance in developing novel anti-prostate cancer agents by combining goji compositions and targeted therapy compounds. American Chemical Society 2022-04-18 /pmc/articles/PMC9069460/ /pubmed/35531567 http://dx.doi.org/10.1021/acsomega.1c03018 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Kazybay, Bexultan
Sun, Qinglei
Dukenbayev, Kanat
Nurkesh, Ayan Amantaiuly
Xu, Na
Kutzhanova, Aidana
Razbekova, Madina
Kabylda, Anar
Yang, Qing
Wang, Qian
Ma, Cuiping
Xie, Yingqiu
Network Pharmacology with Experimental Investigation of the Mechanisms of Rhizoma Polygonati against Prostate Cancer with Additional Herbzymatic Activity
title Network Pharmacology with Experimental Investigation of the Mechanisms of Rhizoma Polygonati against Prostate Cancer with Additional Herbzymatic Activity
title_full Network Pharmacology with Experimental Investigation of the Mechanisms of Rhizoma Polygonati against Prostate Cancer with Additional Herbzymatic Activity
title_fullStr Network Pharmacology with Experimental Investigation of the Mechanisms of Rhizoma Polygonati against Prostate Cancer with Additional Herbzymatic Activity
title_full_unstemmed Network Pharmacology with Experimental Investigation of the Mechanisms of Rhizoma Polygonati against Prostate Cancer with Additional Herbzymatic Activity
title_short Network Pharmacology with Experimental Investigation of the Mechanisms of Rhizoma Polygonati against Prostate Cancer with Additional Herbzymatic Activity
title_sort network pharmacology with experimental investigation of the mechanisms of rhizoma polygonati against prostate cancer with additional herbzymatic activity
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9069460/
https://www.ncbi.nlm.nih.gov/pubmed/35531567
http://dx.doi.org/10.1021/acsomega.1c03018
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